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Colon non tumor
Congenital anomalies
Intestinal neuronal dysplasia

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 11 May 2013, last major update January 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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Diagnosis
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Diagnostic criteria:
  1. Biopsies 8-10 cm above dentate line, sufficient submucosa, 15-20% of ganglia are giant ganglia with more than 8 nerve cells in submucosa of 30 serial sections (Eur J Pediatr Surg 2004;14:384)
  2. Hyperganglionosis of submucous plexus, giant ganglia and rectal biopsies show either ectopic ganglia, increased acetylcholinesterase activity in lamina propria or increased acetylcholinesterase in nerve fibers around submucosal blood vessels (J Pediatr Surg 2001;36:777, Indian J Pathol Microbiol 2004;47:4)

Case reports
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Micro description
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Micro images
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Various images

Positive stains
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End of Colon non tumor > Congenital anomalies > Intestinal neuronal dysplasia


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