Colon non tumor
Colitis (non-infectious)

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 27 December 2016, last major update March 2015

Copyright: (c) 2003-2016,, Inc.

PubMed Search: malakoplakia [title] colon
Cite this page: Malakoplakia. website. Accessed May 21st, 2018.
Definition / general
  • Marked histiocytic infiltrate, more common in bladder, that may diffusely involve colon
  • Usually adults, associated with immunosuppression
  • Due to defective inflammatory response to gram negative bacterial infection
  • Rarely associated with colorectal carcinoma in elderly men (Pathology 2002;34:332)
Case reports
Gross description
  • Diffuse mucosal involvement and submucosal thickening; may cause mass
Microscopic (histologic) description
  • Marked histiocytic infiltrate containing Michaelis-Gutmann bodies (calcospherites) that may resemble signet ring cells at frozen section
Microscopic (histologic) images

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Michaelis-Gutmann bodies

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PAS, calcium

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Liver transplant recipient

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Adjacent to adenocarcinoma

Virtual slides

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Large bowel