Colon tumor - Gastrointestinal autonomic tumor (GANT) of colon

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Colon tumor

Mesenchymal tumors

Gastrointestinal autonomic tumor (GANT) of colon

Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 15 May 2012, last major update May 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Variant of gastrointestinal stromal tumors with ultrastructural neural differentiation
● Requires EM for diagnosis
● Mean age 55 years, usually men
● Rare in colon, more common in small bowel, mesentery and retroperitoneum
● Recommended to consider as same entity as GIST

Case reports
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● 46 year old man with sigmoid tumor with relapse (Tumori 2001;87:349)
● Colonic tumor (Int J Surg Pathol 1998;6:171)

Gross description
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● > 10 cm, well-circumscribed, transmural involvement of bowel wall, tan-pink, lobulated, hemorrhagic with necrosis and cystic degeneration

Micro description
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● Interlacing spindle cells with minimal pleomorphism, 1-2 mitoses / 10 HPF

Micro images
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Spindle cell pattern

Positive stains
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● CD117, vimentin and NSE; variable CD34

Negative stains
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● Muscle markers (usually)

Molecular description
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● c-KIT mutations and loss of 22q13-qter region (Mod Pathol 2002;15:692)

Electron microscopy description
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● Neuron-like cells with axonal cytoplasmic processes
● Synapse like structures
● Dense core neurosecretory granules

Electron microscopy images
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Cellular processes and skenoid fibers

Bulbous axon-like processes with empty vesicles and dense core granules

Additional references
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● Am J Surg Pathol 2002;26:396

End of Colon tumor > Mesenchymal tumors > Gastrointestinal autonomic tumor (GANT) of colon

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