Colon tumor - Hodgkin lymphoma of colon

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Colon tumor

Lymphoma and hematopoietic lesions

Hodgkin lymphoma of colon

Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 22 February 2012, last major update February 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Rare in colon
● Associated with inflammatory bowel disease (Leuk Lymphoma 2001;42:521), chronic inflammation or chronic immunosuppression; all may cause EBV mediated lymphoproliferation (Am J Surg Pathol 2000;24:66)
● Stringent diagnostic criteria necessary due to rarity of primary disease and possible confusion with secondary spread

Case reports
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● 30 year old woman with presentation as polyp (Clin Colorectal Cancer 2001;1:185)
● 42 year old woman with inflammatory bowel disease (Arch Pathol Lab Med 2000;124:1824)
● 62 year old man with acute appendicitis (Clin Transl Oncol 2006;8:450)
● 81 year old man with diverticular disease (Arch Pathol Lab Med 1997;121:528)
● Causing splenic vein obstruction (Indian J Gastroenterol 1994;13:70)

Treatment
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● Discontinuation of immunosuppressive therapy may be helpful

Gross description
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● Transmural involvement of bowel wall, often multifocal, associated with fissuring ulcers and diverticula with abscesses

Micro description
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● Reed-Sternberg cells in background of lymphoid hyperplasia, occasional granulomas

Micro images
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Various images

Positive stains
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● CD15, CD30, EBER1 and LMP1

Negative stains
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● CD45 (LCA)

End of Colon tumor > Lymphoma and hematopoietic lesions > Hodgkin lymphoma of colon

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