Colon tumor
Mesenchymal tumors
Leiomyomatosis-like lymphangioleiomyomatosis

Authors: Raul Gonzalez M.D., Charanjeet Singh, M.D. (see Authors page)

Revised: 14 March 2017, last major update March 2017

Copyright: (c) 2003-2017,, Inc.

PubMed Search: Leiomyomatosis-like OR lymphangioleiomyomatosis colon

Cite this page: Leiomyomatosis-like lymphangioleiomyomatosis. website. Accessed April 23rd, 2017.
Definition / General
  • Multiple lymphangioleiomyomatosis-like lesions involving the colonic wall
Essential Features
  • Unusual manifestation of tuberous sclerosis in the colon
  • Extremely rare (one case report)
  • Almost certainly a manifestation of tuberous sclerosis
Case Reports
  • Resection
Gross Description
  • Diffuse nodular thickening of colonic wall
Gross Images
Images hosted on other servers:

Diffuse wall thickening

Micro Description
  • Mural and mesenteric nodules of spindled cells with elongated nuclei
  • Smooth muscle cells arising in vein walls and melding with lymphatic walls
  • Minimal pleomorphism, no mitotic figures
Micro Images
Images hosted on other servers:

HMB45 positivity in lesional cells

Spindle cells in
colon wall and
smooth muscle cells
arising from vein

Positive Stains
Negative Stains
Differential Diagnosis