Colon tumor - Leiomyomatosis-like lymphangioleiomyomatosis of colon

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Colon tumor

Mesenchymal tumors

Leiomyomatosis-like lymphangioleiomyomatosis of colon

Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 16 May 2012, last major update May 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Extremely rare (one case report)

Case reports
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● 30 year old Chinese woman with tuberous sclerosis (Mod Pathol 2001;14:1141)

Treatment
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● Excision

Gross description
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● Diffuse nodular thickening of colonic wall

Gross images
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Diffuse wall thickening

Micro description
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● Smooth muscle proliferation within colonic wall and also arising from thin walled vessels
● Focal extension into pericolic fat
● No pleomorphism, no atypia, no mitotic figures

Micro images
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Spindle cells in bowel wall, and smooth muscle cells arising from vein

HMB45

Positive stains
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● HMB45 (epithelial cells only), smooth muscle actin, desmin and vimentin

Negative stains
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● CD117, CD34, S100, ER, PgR and bcl2

End of Colon tumor > Mesenchymal tumors > Leiomyomatosis-like lymphangioleiomyomatosis of colon

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