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Colon tumor
Mesenchymal tumors
Leiomyomatosis-like lymphangioleiomyomatosis

Authors: Raul Gonzalez M.D., Charanjeet Singh, M.D. (see Authors page)

Revised: 14 March 2017, last major update March 2017

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: Leiomyomatosis-like OR lymphangioleiomyomatosis colon

Table of Contents
Definition / general | Essential features | Etiology | Case reports | Treatment | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Differential diagnosis
Cite this page: Leiomyomatosis-like lymphangioleiomyomatosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colontumorLAM.html. Accessed July 14th, 2017.
Definition / general
  • Multiple lymphangioleiomyomatosis-like lesions involving the colonic wall
Essential features
  • Unusual manifestation of tuberous sclerosis in the colon
  • Extremely rare (one case report)
Etiology
  • Almost certainly a manifestation of tuberous sclerosis
Case reports
Treatment
  • Resection
Gross description
  • Diffuse nodular thickening of colonic wall
Gross images
Images hosted on other servers:

Diffuse wall thickening

Microscopic (histologic) description
  • Mural and mesenteric nodules of spindled cells with elongated nuclei
  • Smooth muscle cells arising in vein walls and melding with lymphatic walls
  • Minimal pleomorphism, no mitotic figures
Microscopic (histologic) images
Images hosted on other servers:

HMB45 positivity in lesional cells

Spindle cells in
colon wall and
smooth muscle cells
arising from vein

Positive stains
Negative stains
Differential diagnosis
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