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Colon tumor

Other tumors

Langerhans cell histiocytosis of colon


Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 2 May 2012, last major update May 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Uncommon site; present in ~10% of children with multisystemic disease (J Pediatr Gastroenterol Nutr 1999;29:462)
● Diagnose by rectal biopsy

Case reports
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● 5 month old baby with GI bleeding (J Pediatr Gastroenterol Nutr 1985;4:286)

Clinical images
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Rectal tumors

Micro description
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● Aggregates of histiocytic cells with grooved nuclei, eosinophil rich background

Micro images
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Rectal tumors

Positive stains
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Histiocytes: CD1a, CD64 and S100

Differential diagnosis
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Non-Langerhans histiocytoses: CD1a negative, CD64+

End of Colon tumor > Other tumors > Langerhans cell histiocytosis of colon


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