Pathology Outlines - Langerhans cell histiocytosis

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Colon tumor
Other tumors
Langerhans cell histiocytosis

Author: Charanjeet Singh, M.D. (see Authors page)

Revised: 4 January 2017, last major update May 2012

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed search: Langerhans cell histiocytosis colon

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Table of Contents

Definition / general | Case reports | Clinical images | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Differential diagnosis

Cite this page: Langerhans cell histiocytosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colontumorLCH.html. Accessed July 14th, 2017.

Definition / general

Uncommon site; present in ~10% of children with multisystemic disease (J Pediatr Gastroenterol Nutr 1999;29:462)
Diagnose by rectal biopsy

Case reports

5 month old baby with GI bleeding (J Pediatr Gastroenterol Nutr 1985;4:286)

Clinical images

Images hosted on other servers:

Rectal tumors

Microscopic (histologic) description

Aggregates of histiocytic cells with grooved nuclei, eosinophil rich background

Microscopic (histologic) images

Images hosted on other servers:

Rectal tumors

Positive stains

Histiocytes: CD1a, CD64 and S100

Differential diagnosis

Non Langerhans histiocytoses: CD1a negative, CD64+

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