Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 16 October 2011, last major update September 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.
● Very rare in colon
● Associated with EBV
● Rectal tumor associated with EBV (Pathol Res Pract 2001;197:577)
● In Lynch syndrome with colonic mucinous and well-differentiated adenocarcinomas (Arch Pathol Lab Med 1999;123:720)
● With tumors at other sites (Dis Colon Rectum 1998;41:925)
● Associated with ulcerative colitis (J Gastroenterol 2007;42:181)
● Syncytial growth pattern of undifferentiated pleomorphic malignant epithelial cells with ill-defined borders, prominent nucleoli, brisk mitotic activity, prominent stromal and intratumoral lymphoid infiltrate
● Focal necrosis
● Infiltrative margins
Pale islands of tumor cells surrounded by lymphocytes
Tumor cells and infiltrating lymphocytes
Tumor cells have pale, vesicular nuclei
● Cytokeratin (AE1/AE3, CAM 5.2), EBV (often) and p53 (10% of tumor cells)
● Mucin (may be focal), neuroendocrine markers and S100
● Medullary carcinoma: lymphocytic infiltrates are peritumoral, not intratumoral; pushing not infiltrative margins, monomorphic tumor cells
End of Colon tumor > Carcinoma > Lymphoepithelioma-like carcinoma
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