Home   Chapter Home   Jobs   Conferences   Fellowships   Books


Colon tumor


Lymphoepithelioma-like carcinoma

Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 16 October 2011, last major update September 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.


● Very rare in colon
● Associated with EBV

Case reports

● Rectal tumor associated with EBV (Pathol Res Pract 2001;197:577)
● In Lynch syndrome with colonic mucinous and well-differentiated adenocarcinomas (Arch Pathol Lab Med 1999;123:720)
● With tumors at other sites (Dis Colon Rectum 1998;41:925)
● Associated with ulcerative colitis (J Gastroenterol 2007;42:181)

Micro description

● Syncytial growth pattern of undifferentiated pleomorphic malignant epithelial cells with ill-defined borders, prominent nucleoli, brisk mitotic activity, prominent stromal and intratumoral lymphoid infiltrate
● Focal necrosis
● Infiltrative margins

Micro images

Bladder tumor

Lung tumors:

Pale islands of tumor cells surrounded by lymphocytes

Tumor cells and infiltrating lymphocytes

Tumor cells have pale, vesicular nuclei

Positive stains

● Cytokeratin (AE1/AE3, CAM 5.2), EBV (often) and p53 (10% of tumor cells)

Negative stains

● Mucin (may be focal), neuroendocrine markers and S100

Differential diagnosis

Medullary carcinoma: lymphocytic infiltrates are peritumoral, not intratumoral; pushing not infiltrative margins, monomorphic tumor cells

End of Colon tumor > Carcinoma > Lymphoepithelioma-like carcinoma

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).