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Colon tumor

Mesenchymal tumors

Leiomyosarcoma of colon


Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 16 May 2012, last major update May 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Rare in colon; less common than GIST
● Infantile tumors have favorable prognosis (J Pediatr Surg 2004;39:1257); adult patients often die of disease
● May be a rare late effect of pelvic radiation (Hepatogastroenterology 2003;50:1933, Am Surg 1999;65:6)

Gross description
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● Intraluminal, bulging and polypoid mass

Gross images
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Leiomyosarcoma vs. GIST

Micro description
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● Resembles smooth muscle but with high grade histology
● Rarely has osteoclast-like giant cells (Arch Pathol Lab Med 2004;128:440)

Micro images
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Well differentiated tumor

   
Left: moderately differentiated; right-poorly differentiated


Spindle and epithelioid tumors with osteoclast-like giant cells

Virtual images
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Leiomyosarcoma

Positive stains
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● Smooth muscle actin, desmin

Negative stains
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● CD117, CD34 and S100

Molecular description
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● No c-kit mutations

Differential diagnosis
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Metastatic leiomyosarcoma (South Med J 1997;90:1238)

Additional references
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Am J Surg Pathol 2000;24:1339

End of Colon tumor > Mesenchymal tumors > Leiomyosarcoma of colon


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