Colon tumor
Mesenchymal tumors
Müllerian adenosarcoma

Topic Completed: 1 June 2017

Revised: 9 July 2019

Copyright: 2003-2019,, Inc.

PubMed search: Colonic müllerian adenosarcoma

Raul S. Gonzalez, M.D.
Page views in 2019: 205
Page views in 2020 to date: 29
Cite this page: Gonzalez R. Müllerian adenosarcoma. website. Accessed February 24th, 2020.
Definition / general
  • Biphasic gynecologic tumor composed of benign epithelium and malignant stroma
Essential features
  • Rare in gastrointestinal tract
  • Second most common colonic lesion to arise from endometriosis, after endometrioid adenocarcinoma
Clinical features
  • Abdominal pain (may be due to the endometriosis)
  • Patients appear to have good prognosis, but few cases reported
Gross description
  • Large (up to 15 cm) solid / cystic mass involving the muscularis propria
Microscopic (histologic) description
  • Biphasic tumor containing endometrioid glands and stroma
  • Glandular component is benign but may show focal atypia
  • Stromal component shows mitotic figures, mild to moderate atypia, condensation around glands and sometimes pseudodecidualization
Microscopic (histologic) images

Contributed by Weijie Li, MD:

Uterine adenosarcoma

Differential diagnosis
Board review style question #1
    The most common malignancy arising in colonic endometriosis is:

  1. Colorectal adenocarcinoma
  2. Endometrioid adenocarcinoma
  3. Endometrioid adenofibroma
  4. Endometrioid stromal sarcoma
  5. Müllerian adenosarcoma
Board review answer #1
B. Endometrioid adenocarcinoma

Reference: Colon tumor - Müllerian adenosarcoma

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