Adenosquamous carcinoma

Colon tumor
Carcinoma
Adenosquamous carcinoma

Author: Raul Gonzalez M.D. (see Authors page)

Revised: 27 December 2016, last major update February 2015

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Adenosquamous carcinoma [title] colon

Table of Contents

Cite this page: Adenosquamous carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colontumoradenosquamous.html. Accessed July 14th, 2017.

Definition / general

Rare (0.1% of colonic carcinomas) epithelial tumor of colon with glandular and squamous elements (Am J Surg Pathol 1978;2:47)
Has higher metastatic rate and worse prognosis than conventional colorectal adenocarcinoma (Dis Colon Rectum 2012;55:509, Dis Colon Rectum 1999;42:258)

Sites

Typically arises in right colon (Dis Colon Rectum 2001;44:341)

Pathophysiology

HPV infection does not appear to play a role (Surg Today 2009;39:619, Eur J Surg Oncol 2002;28:657)

Clinical features

Tumor stage is often advanced at presentation (Dis Colon Rectum 1996;39:1265)
May cause paraneoplastic hypercalcemia (Int J Clin Oncol 2005;10:144, Am Surg 2001;67:585)
Can occur in patients with ulcerative colitis (Dis Colon Rectum 1988;31:323)

Case reports

71 year old man with adenosquamous carcinoma of sigmoid colon (Int J Clin Exp Med 2013;6:390)
78 year old woman with associated paraneoplastic hypercalcemia (Int J Clin Oncol 2005;10:144)
Adenosquamous carcinoma of colon (Am Surg 2006;72:754) and colorectum (J Exp Clin Cancer Res 2001;20:293)

Treatment