Colon tumor
Mesenchymal tumors
Angiosarcoma of colon


Topic Completed: 1 August 2016

Revised: 8 July 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Angiosarcoma of colon


Raul S. Gonzalez, M.D.
Page views in 2018: 331
Page views in 2019 to date: 300
Cite this page: Gonzalez R. Angiosarcoma of colon. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colontumorangiosarcoma.html. Accessed September 17th, 2019.
Definition / general
  • Aggressive vascular neoplasm that is very rare in the gastrointestinal tract, either as a primary or as a metastasis
Essential features
  • Rare and often fatal vascular malignancy
  • Sheets of malignant epithelioid cells with subtle cleft formation, suggesting vascular differentiation
Sites
  • May be slightly more common in the small intestine than the large intestine
Clinical features
  • Median age 57 years (Am J Surg Pathol 2004;28:298)
  • Symptoms include anemia, intestinal bleeding and pain
  • Primary lesions more commonly reported than metastases
  • Often fatal
Case reports
Treatment
  • Resection, chemotherapy, radiation
Microscopic (histologic) description
  • Sheets of malignant epithelioid cells with subtle cleft formation, suggesting vascular differentiation
  • Can have pseudogladular elements, simulating adenocarcinoma
  • Rarely well differentiated and more obviously vascular
Microscopic (histologic) images

Contributed by Raul S. Gonzalez, M.D.

Various images



Images hosted on other servers:

Pelvic metastasis:
cytology, AE1 / AE3
Liver metastasis:
H&E, CD34

Positive stains
Negative stains
Differential diagnosis
  • Primary or metastatic poorly differentiated carcinoma: negative for vascular markers
  • Melanoma: positive for S100
  • Florid vascular proliferation due to prolapse or intussusception (Mod Pathol 2001;14:1114): minimal atypia; mitoses rare
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