Colon tumor
Mesenchymal tumors
Angiosarcoma of colon

Author: Raul S. Gonzalez, M.D. (see Authors page)

Revised: 4 August 2016, last major update August 2016

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Angiosarcoma of colon

Definition / General
  • Aggressive vascular neoplasm that is very rare in the gastrointestinal tract, either as a primary or as a metastasis
Essential Features
  • Rare and often fatal vascular malignancy
  • Sheets of malignant epithelioid cells with subtle cleft formation, suggesting vascular differentiation
Sites
  • May be slightly more common in the small intestine than the large intestine
Clinical Features
  • Median age 57 years (Am J Surg Pathol 2004;28:298)
  • Symptoms include anemia, intestinal bleeding and pain
  • Primary lesions more commonly reported than metastases
  • Often fatal
Case Reports
Treatment
  • Resection, chemotherapy, radiation
Micro Description
  • Sheets of malignant epithelioid cells with subtle cleft formation, suggesting vascular differentiation
  • Can have pseudogladular elements, simulating adenocarcinoma
  • Rarely well differentiated and more obviously vascular
Micro Images

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Courtesy of Raul S. Gonzalez, M.D.



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Pelvic metastasis: cytology, AE1/AE3
Liver metastasis: H&E, CD34

Positive Stains
Negative Stains
Differential Diagnosis
  • Primary or metastatic poorly differentiated carcinoma: negative for vascular markers
  • Melanoma: positive for S100
  • Florid vascular proliferation due to prolapse or intussusception (Mod Pathol 2001;14:1114): minimal atypia; mitoses rare