Colon tumor - Angiosarcoma of colon

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Colon tumor

Mesenchymal tumors

Angiosarcoma of colon

Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 26 March 2012, last major update March 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Very rare in GI tract as primary or metastasis
● In GI series, median age 57 years (range 25-85 years, Am J Surg Pathol 2004;28:298)
● Often death due to disease

Case reports
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● Teenage boy (Acta Chir Belg 2004;104:465)
● 55 year old man with Cecal tumor (Indian J Gastroenterol 1995;14:31)
● 61 year old man with prior surgery (World J Surg Oncol 2005;3:60)
● 71 year old man with colonic metastases from liver (Arch Pathol Lab Med 2001;125:968)
● 77 year old man with rectal bleeding and obstruction (Dis Colon Rectum 2004;47:2202)
● Associated with retained surgical sponge (Am J Clin Pathol 1992;97:416)
● Metastatic into tubular adenoma (Tumori 2005;91:210)

Gross images
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5 cm mass with abscess and granulation tissue

Micro description
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● Sheets of malignant appearing epithelioid cells with subtle areas of cleft-like spaces suggestive of vascular differentiation

Micro images
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Associated with prior surgery

Metastasis from liver - A: FNA; B: AE1-3; C: H&E of liver primary; D: CD31

Positive stains
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● CD31, CD34, Factor VIII, AE1-AE3
● Variable Cam 5.2 / CK8, CK19, CK7

Negative stains
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● CK20, S100 and EMA (usually)

Differential diagnosis
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● Primary or metastatic carcinoma
● Melanoma
● Florid vascular proliferation due to prolapse or intussusception (Mod Pathol 2001;14:1114)

End of Colon tumor > Mesenchymal tumors > Angiosarcoma of colon

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