Biopsies of colon
Reviewers: Shilpa Jain, M.D. (see Reviewers page)
Revised: 15 May 2012, last major update May 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Recommended to submit entire biopsy material and cut 3 levels
● If clinically is a polyp but microscopically is normal, flipping specimen after melting paraffin block gives definitive diagnosis in 30% of cases (Am J Surg Pathol 2003;27:254)
● Deeper levels may reveal polyps in negative biopsies (Am J Clin Pathol 2002;117:424)
● Difficult to diagnose carcinoma (i.e. invasion into submucosa) if no submucosa is present
● Can diagnose invasion if (a) marked desmoplasia, (b) infiltrative pattern, (c) ulceration or (d) clinical mass lesion
● Muciphages, without other abnormalities, have no clinical significance (Histopathology 2000;36:556)
End of Colon tumor > Polyps > Biopsies of colon
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