Colon tumor
Biopsies of colon

Author: Shilpa Jain, M.D. (see Authors page)

Revised: 7 December 2016, last major update May 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: biopsies[title] colon

Table of Contents
Definition / general
Cite this page: Biopsies of colon. website. Accessed December 11th, 2018.
Definition / general
  • Recommended to submit entire biopsy material and cut 3 levels
  • If clinically is a polyp but microscopically is normal, flipping specimen after melting paraffin block gives definitive diagnosis in 30% of cases (Am J Surg Pathol 2003;27:254)
  • Deeper levels may reveal polyps in negative biopsies (Am J Clin Pathol 2002;117:424)
  • Difficult to diagnose carcinoma (i.e. invasion into submucosa) if no submucosa is present
  • Can diagnose invasion if (a) marked desmoplasia, (b) infiltrative pattern, (c) ulceration or (d) clinical mass lesion
  • Muciphages, without other abnormalities, have no clinical significance (Histopathology 2000;36:556)