Colon tumor - Burkitt’s lymphoma of colon

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Colon tumor

Lymphoma and hematopoietic lesions

Burkitt’s lymphoma of colon

Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 21 February 2012, last major update February 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● See also Lymphoma and plasma cell neoplasms chapter
● Sporadic cases in Western world and Middle East may present with ileocecal involvement and pain or obstruction
● Endemic cases in Africa usually don’t present with GI involvement

Case reports
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● 2 year old boy with wide-based polyp (Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 1996;37:373)
● 32 year old man with Crohn’s colitis (J Clin Gastroenterol 2003;36:332)

Micro description
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● Small, non-cleaved and monomorphic cells with basophilic cytoplasm, round nuclei and prominent multiple nucleoli
● Starry sky appearance on low power

Micro images
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Not necessarily colon:

Left to right: Burkitt (figure A/B) versus diffuse large B cell lymphoma; starry sky appearance; Ki-67

Cytology description
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● Vacuoles

Cytology images
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Touch prep shows prominent vacuoles

Positive stains
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● CD20, CD10
● Ki-67 staining in > 90% of cells

Negative stains
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● CD5, CD23

Molecular description
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● C-myc translocations [t(8;14) and others]

End of Colon tumor > Lymphoma and hematopoietic lesions > Burkitt’s lymphoma of colon

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