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Colon tumor

Polyps

Inflammatory Cap polyp


Reviewers: Shilpa Jain, M.D. (see Reviewers page)
Revised: 14 October 2011, last major update August 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

Definition
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● First described in an abstract in 1985 (Br J Surg 1985; 72 (Suppl) S133)
● Rare
● Etiology unknown, but may be associated with mucosal prolapse (Gut 1993;34:562)
● Often presents with mucoid or bloody diarrhea and hypoproteinemia
Endoscopy: multiple sessile rectosigmoid polyps with adherent white flecks with normal intervening mucosa (Endoscopy 2001;33:262)

Case reports
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● 28 year old man with ulcerative colitis (Case of the Week #102)

Treatment
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● Traditionally polypectomy or partial colectomy (Dis Colon Rectum 2004;47:1208)
● Also medical treatment in patients with H. pylori gastritis (Helicobacter 2004;9:651) and using infliximab, an antibody to tumor necrosis alpha (Gastroenterology 2004;126:1868)

Gross description
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● Multiple, distinctive, inflammatory rectosigmoid polyps

Gross images
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Multiple colonic polyps

Micro description
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● Inflamed mucosa with tortuous, elongated crypts attenuated towards the mucosal surface with abundant inflammation in the lamina propria and characteristic ”cap” of inflamed and ulcerated granulation tissue on the mucosal surface

Micro images
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Various images from Case of Week #102

       

Inflammatory polyp of colon secondary to mucosal prolapse

Differential diagnosis
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● Amebic colitis
● Antibiotic associated colitis
● Inflammatory bowel disease

End of Colon tumor > Polyps > Inflammatory Cap polyp


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