Colon tumor
Polyps
Invasive carcinoma arising in a colonic adenoma

Author: Shilpa Jain, M.D. (see Authors page)

Revised: 5 December 2016, last major update September 2010

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Invasive carcinoma arising colonic adenoma
Cite this page: Invasive carcinoma arising in a colonic adenoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colontumorcarcinomaarising.html. Accessed January 20th, 2017.
Definition / General
  • Invasive only if cancer has invaded beyond muscularis mucosa into submucosa
  • Can diagnose invasion without identification of submucosa if (a) marked desmoplasia, (b) infiltrative pattern, (c) ulceration or (d) clinical mass lesion
Terminology
  • Recommended to NOT use "carcinoma in situ" terminology in colorectum; use either high grade dysplasia or invasive carcinoma
Epidemiology
Prognostic Factors
  • Recurrent disease, nodal metastases or residual local disease: 20% incidence if cancer is near margin, is poorly differentiated or if angiolymphatic invasion is present
Case Reports
Treatment
Gross Images

Images hosted on other servers:

Adenocarcinoma arising in villous adenoma

Micro Description
  • How to Report:
    • Report type of carcinoma, grade, presence of angiolymphatic invasion (tumor emboli in true endothelial lined channels away from tumor, not retraction artifact), status of resection margins (close to margin is within one high power field or 1-2 mm from diathermy or at diathermy), presence of dysplasia
    • Sample report #1: poorly differentiated carcinoma arising within an adenoma, extending to resection margin, no angiolymphatic invasion
    • Sample report #2: moderately differentiated carcinoma arising with an adenoma; tumor 2.5 cm from resection margin, no angiolymphatic invasion
Micro Images

Images hosted on other servers:

Adenocarcinoma arising in tubular adenoma

Arising in villous adenoma

Metastatic signet ring adenocarcinoma in adenoma