Colon tumor

Topic Completed: 1 February 2015

Minor changes: 29 June 2020

Copyright: 2002-2019,, Inc.

PubMed Search: Carcinosarcoma [title] colon

Raul S. Gonzalez, M.D.
Page views in 2019: 472
Page views in 2020 to date: 273
Cite this page: Gonzalez R. Carcinosarcoma. website. Accessed July 13th, 2020.
Definition / general
  • Biphasic colorectal neoplasm composed of epithelial and mesenchymal elements
  • Poor prognosis
  • Distinct from "sarcomatoid carcinoma," which is an entirely epithelial malignancy with some sarcoma-like morphologic features (such as spindled cells); this distinction has been overlooked in many reports
  • Extremely rare in the colon; only reported in single case reports
  • May be more common in left colon
Case reports
Gross images

Images hosted on other servers:

Polypoid carcinosarcoma of cecum

Microscopic (histologic) description
  • Neoplasm with epithelial component (typically adenocarcinoma) and mesenchymal component (varies; most common are leiomyosarcoma, osteosarcoma, chondrosarcoma)
Microscopic (histologic) images

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Carcinosarcoma with two distinct components

Mesenchymal component is SMA+

Epithelial component only is keratin+

Vimentin and cytokeratin

Positive stains
Electron microscopy images

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Epithelial and mesenchymal components

Molecular / cytogenetics description
  • One case demonstrated identical TP53 gene mutations in both tumor elements, suggesting common origin (BMC Cancer 2006;6:185)
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