Clear cell carcinoma of colon

Colon tumor
Carcinoma
Clear cell carcinoma

Author: Raul S. Gonzalez, M.D.

Topic Completed: 1 March 2015

Minor changes: 25 June 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: "Clear cell carcinoma" colon

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Page views in 2020 to date: 347

Table of Contents

Cite this page: Gonzalez R. Clear cell carcinoma of colon. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colontumorclearcell.html. Accessed June 1st, 2020.

Definition / general

Rare variant of adenocarcinoma, with fewer than 20 cases reported (Oncol Lett 2014;8:1873)
Demonstrates clear cell features due to intracytoplasmic glycogen

Epidemiology

Usually arises in men, in the descending colon (J La State Med Soc 2014;166:143)

Pathophysiology

Can arise from a tubular adenoma also showing clear cell morphology (Am J Surg Pathol 2010;34:1344)

Case reports

41 year old woman with clear cell adenocarcinoma of the colon (Case Rep Oncol Med 2014;2014:905478)
65 year old woman with clear cell adenocarcinoma of the colon arising in endometriosis (J Clin Pathol 2001;54:76)
68 year old man with clear cell adenocarcinoma of the colon (J Clin Pathol 1995;48:1142)
81 year old man with clear cell adenocarcinoma with enteroblastic differentiation (J Clin Oncol 2011;29:e647)
89 year old woman with clear cell adenocarcinoma of the colon (Int J Colorectal Dis 2004;19:264)

Clinical images

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