Colon tumor
Clear cell carcinoma

Topic Completed: 1 March 2015

Minor changes: 25 June 2019

Copyright: 2002-2019,, Inc.

PubMed Search: "Clear cell carcinoma" colon

Raul S. Gonzalez, M.D.
Page views in 2019: 649
Page views in 2020 to date: 347
Cite this page: Gonzalez R. Clear cell carcinoma of colon. website. Accessed June 1st, 2020.
Definition / general
  • Rare variant of adenocarcinoma, with fewer than 20 cases reported (Oncol Lett 2014;8:1873)
  • Demonstrates clear cell features due to intracytoplasmic glycogen
Case reports
Clinical images

Images hosted on other servers:

Stenotic tumor on colonoscopy

Microscopic (histologic) description
  • Resembles normal colorectal adenocarcinoma, except cells show prominent cytoplasmic clearing
Microscopic (histologic) images

Contributed by Raul Gonzalez, M.D.

Various images

Images hosted on other servers:

Glandular arrangement of clear cells

Vesicular nuclei and prominent nucleoli

H&E, CDX2+

Positive stains
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