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Table of Contents
Definition / general | Epidemiology | Pathophysiology | Case reports | Clinical images | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Differential diagnosisCite this page: Gonzalez R. Clear cell carcinoma of colon. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colontumorclearcell.html. Accessed March 23rd, 2019.
Definition / general
- Rare variant of adenocarcinoma, with fewer than 20 cases reported (Oncol Lett 2014;8:1873)
- Demonstrates clear cell features due to intracytoplasmic glycogen
Epidemiology
- Usually arises in men, in the descending colon (J La State Med Soc 2014;166:143)
Pathophysiology
- Can arise from a tubular adenoma also showing clear cell morphology (Am J Surg Pathol 2010;34:1344)
Case reports
- 41 year old woman with clear cell adenocarcinoma of the colon (Case Rep Oncol Med 2014;2014:905478)
- 65 year old woman with clear cell adenocarcinoma of the colon arising in endometriosis (J Clin Pathol 2001;54:76)
- 68 year old man with clear cell adenocarcinoma of the colon (J Clin Pathol 1995;48:1142)
- 81 year old man with clear cell adenocarcinoma with enteroblastic differentiation (J Clin Oncol 2011;29:e647)
- 89 year old woman with clear cell adenocarcinoma of the colon (Int J Colorectal Dis 2004;19:264)
Clinical images
Images hosted on other servers:
Stenotic tumor on colonoscopy
Microscopic (histologic) description
- Resembles normal colorectal adenocarcinoma, except cells show prominent cytoplasmic clearing
Microscopic (histologic) images
Images hosted on other servers:
Glandular arrangement of clear cells
Vesicular nuclei and prominent nucleoli
H&E, CDX2+
Images courtesy of Dr. Raul Gonzalez::
Various images
Various images
Positive stains
- CK20, CDX2, weak MUC2 (Am J Surg Pathol 2010;34:1344)
Negative stains
Differential diagnosis
