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Colon tumor

Carcinoma

Clear cell carcinoma of colon

Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 14 October 2011, last major update September 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

Clinical features
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● Variant of adenocarcinoma with intracytoplasmic glycogen
● Usually left colon
● Usually elderly men

Case reports
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● 65 year old woman with coexisting endometriosis (J Clin Pathol 2001;54:76)
● 68 year old man with death due to liver metastases (J Clin Pathol 1995;48:1142)
● 81 year old man with dizziness (J Clin Oncol 2011;29:e647)
● 89 year old woman (Int J Colorectal Dis 2004;19:264)

Micro images
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Glandular arrangement of clear cells


With vesicular nuclei and prominent nucleoli

Positive stains
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● PAS, CEA

Negative stains
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● Mucin

Differential diagnosis
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● Metastatic renal cell carcinoma: CEA-

End of Colon tumor > Carcinoma > Clear cell carcinoma of colon

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