Colon tumor - Mucinous (colloid) carcinoma of colon

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Colon tumor

Carcinoma

Mucinous (colloid) carcinoma of colon

Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 23 December 2011, last major update September 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

Clinical features
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● Defined as having mucin lakes comprising 50% or more of tumor mass
● Relatively common (10% of all colorectal carcinomas), usually in rectum
● Associated with microsatellite instability (Cancer 2005;103:2023)
● Associated with villous adenomas, ulcerative colitis or other colitis, prior pelvic radiation (Cancer 1976;37:1891)
● Usually presents with more advanced stage (Dis Colon Rectum 1993;36:49), greater nodal involvement (Gastroenterol Hepatol 2002;25:534) than non-mucinous tumors, but see (J Med Assoc Thai 2006;89:25)
● Similar prognosis by stage as other carcinomas

Case reports
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● 11 year old girl (J Postgrad Med 1993;39:218)
● 79 year old man with tumor arising from perianal fistula (Dig Surg 2003;20:69)

Gross description
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● Exophytic, gelatinous

Gross images
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Mucinous tumor arising in villous adenoma

Sigmoidorectal intussusception caused by a mucinous adenocarcinoma of the sigmoid colon

Cecal tumor

Micro description
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● Bland tumor cells floating in large extracellular mucin lakes comprising 50%+ of tumor mass
● May have signet ring cells (with intracellular mucin)

Micro images
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Large mucin pools containing tumor cells

Various images from breast

Positive stains
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● CDX2 (100%), MUC2 (100%), CK20 (98%), beta-catenin (nuclear) (64%); also CK7 (19%, usually from rectum/anus), MUC6 (5%) (Am J Surg Pathol 2011;35:1830)

Differential diagnosis
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● Signet ring carcinoma: no mucin lakes

Additional references
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● Dis Colon Rectum 2005;48:1161

End of Colon tumor > Carcinoma > Mucinous (colloid) carcinoma of colon

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