Colon tumor
Familial polyposis syndromes of colon
Cronkhite-Canada syndrome

Author: Michael Feely, D.O. (see Authors page)
Editor: Raul Gonzalez, M.D.

Revised: 27 December 2016, last major update August 2015

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Cronkhite Canada syndrome [title] colon

Cite this page: Cronkhite-Canada syndrome. website. Accessed October 19th, 2018.
Definition / general
  • Rare, nonhereditary polyposis syndrome of unknown etiology
  • Disorder of middle adulthood, with mean age of diagnosis of 59 years
  • Poor prognosis due to associated nutritional complications
  • Up to 50% have remissions
  • Rarely has a fulminant course (Endoscopy 2010;42:E350)
  • Associated carcinomas documented in 15% - 25% of cases (J Clin Pathol. 2014;67:891)
  • Polyps affect entire gastrointestinal tract, except the esophagus
  • Also associated with ectodermal changes including alopecia, nail atrophy and cutaneous hyperpigmentation
  • No known genetic link; considered nonhereditary
  • May represent an autoimmune disorder (Digestion 2007;75:96)
Clinical features
  • Patients present with variable symptoms, including diarrhea, weight loss, nausea, GI bleeding, protein losing enteropathy
Case reports
Clinical images

Images hosted on other servers:

Upper endoscopy: gastric polyposis

Microscopic (histologic) description
  • Multiple ill defined polyps with cystically dilated glands and crypts associated with an edematous lamina propria containing mononuclear cells and eosinophils, microscopically indistinguishable from juvenile polyps (Am J Surg Pathol 1989;13:940)
  • Intervening nonpolypoid mucosa characteristically also has dilated glands, edema, congestion and inflammation (Gastroenterol Res Pract 2009;2009:619378)
Microscopic (histologic) images

Images hosted on other servers:

Polyp with dilated glands

Duodenum / small intestine

Images courtesy of Raul Gonzalez, M.D. and Mike Feely, D.O.:

Duodenum: elongated, irregular and cystic crypts; lamina propria has mixed inflammatory infiltrate

Colon: polypoid mucosa with cystically dilated glands and lamina propria expansion

Differential diagnosis