Cronkhite-Canada syndrome

Topic Completed: 1 August 2015

Minor changes: 1 October 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Cronkhite Canada syndrome [title] colon

Michael Feely, D.O.
Raul S. Gonzalez, M.D.
Page views in 2019: 1,165
Page views in 2020 to date: 1,375
Cite this page: Feely M, Gonzalez R. Cronkhite-Canada syndrome. website. Accessed October 20th, 2020.
Definition / general
  • Rare, nonhereditary polyposis syndrome of unknown etiology
  • Disorder of middle adulthood, with mean age of diagnosis of 59 years
  • Poor prognosis due to associated nutritional complications
  • Up to 50% have remissions
  • Rarely has a fulminant course (Endoscopy 2010;42:E350)
  • Associated carcinomas documented in 15% - 25% of cases (J Clin Pathol. 2014;67:891)
  • Polyps affect entire gastrointestinal tract, except the esophagus
  • Also associated with ectodermal changes including alopecia, nail atrophy and cutaneous hyperpigmentation
  • No known genetic link; considered nonhereditary
  • May represent an autoimmune disorder (Digestion 2007;75:96)
Clinical features
  • Patients present with variable symptoms, including diarrhea, weight loss, nausea, GI bleeding, protein losing enteropathy
Case reports
Clinical images

Images hosted on other servers:

Upper endoscopy: gastric polyposis

Microscopic (histologic) description
  • Multiple ill defined polyps with cystically dilated glands and crypts associated with an edematous lamina propria containing mononuclear cells and eosinophils, microscopically indistinguishable from juvenile polyps (Am J Surg Pathol 1989;13:940)
  • Intervening nonpolypoid mucosa characteristically also has dilated glands, edema, congestion and inflammation (Gastroenterol Res Pract 2009;2009:619378)
Microscopic (histologic) images

Contributed by Raul Gonzalez, M.D. and Mike Feely, D.O.

Duodenum: elongated, irregular and cystic crypts; lamina propria has mixed inflammatory infiltrate

Colon: polypoid mucosa with cystically dilated glands and lamina propria expansion

Images hosted on other servers:

Polyp with dilated glands

Duodenum / small intestine

Differential diagnosis
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