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Colon tumor


Displaced glands / pseudoinvasion of colon

Reviewers: Shilpa Jain, M.D. (see Reviewers page)
Revised: 29 September 2014, last major update August 2011
Copyright: (c) 2003-2014, PathologyOutlines.com, Inc.

Clinical features

● Also called epithelial misplacement
● Presence of dysplastic glands from an adenoma beneath the muscularis mucosa due to biopsy related torsion or other trauma
● A low power diagnosis
● Occurs in 3% of adenomas, usually with well-defined stalks
● Resembles intramucosal carcinoma, but cytologic features resemble adenoma
● See also hyperplastic polyp with misplaced epithelium

Micro description

● Submucosal glands surrounded by loose inflamed stroma and granulation tissue, but not desmoplastic stroma
● Glands may have atypia associated with adenoma, but not carcinoma

Negative stains

● p53, E-cadherin and type IV collagen (Am J Surg Pathol 2002;26:206)

Additional references

Am J Surg Pathol 1993;17:1262, Cancer 1974;33:206

End of Colon tumor > Polyps > Displaced glands / pseudoinvasion of colon

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