Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Colon tumor

Polyps

Fibroblastic polyp of colon


Reviewers: Shilpa Jain, M.D. (see Reviewers page)
Revised: 15 October 2011, last major update August 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

Definition
=========================================================================

● Initially described in 2004 (Am J Surg Pathol 2004;28:374)
● May be due to exuberant response to tissue injury (J Clin Gastroenterol 2005;39:778)
● May be early stage of inflammatory fibrous polyp (Am J Surg Pathol 2004;28:1397)
● Solitary, usually in sigmoid colon

Treatment
=========================================================================

● Excision (benign behavior)

Gross description
=========================================================================

● 2-4 mm

Micro description
=========================================================================

● Mucosal polyp composed of bland, plump spindle cells in lamina propria with fibroblastic features
● Spindle cells associated with muscularis mucosa cause separation and disorganization of colonic crypts
● Often associated with serrated/hyperplastic crypts
● No atypia, no mitotic activity and no necrosis

Positive stains
=========================================================================

● Vimentin; occasional weak/focal CD34 or smooth muscle actin

Negative stains
=========================================================================

● Desmin, CD31, CD68, bcl2, c-kit, S100 and EMA

EM description
=========================================================================

● Sparse cytoplasmic organelles, many intermediate filaments

Additional References
=========================================================================

Histopathology 2006;48:431

End of Colon tumor > Polyps > Fibroblastic polyp of colon


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).