Colon tumor - Fibroblastic polyp of colon

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Colon tumor

Polyps

Fibroblastic polyp of colon

Reviewers: Shilpa Jain, M.D. (see Reviewers page)
Revised: 15 October 2011, last major update August 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

Definition
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● Initially described in 2004 (Am J Surg Pathol 2004;28:374)
● May be due to exuberant response to tissue injury (J Clin Gastroenterol 2005;39:778)
● May be early stage of inflammatory fibrous polyp (Am J Surg Pathol 2004;28:1397)
● Solitary, usually in sigmoid colon

Treatment
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● Excision (benign behavior)

Gross description
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● 2-4 mm

Micro description
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● Mucosal polyp composed of bland, plump spindle cells in lamina propria with fibroblastic features
● Spindle cells associated with muscularis mucosa cause separation and disorganization of colonic crypts
● Often associated with serrated/hyperplastic crypts
● No atypia, no mitotic activity and no necrosis

Positive stains
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● Vimentin; occasional weak/focal CD34 or smooth muscle actin

Negative stains
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● Desmin, CD31, CD68, bcl2, c-kit, S100 and EMA

EM description
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● Sparse cytoplasmic organelles, many intermediate filaments

Additional References
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● Histopathology 2006;48:431

End of Colon tumor > Polyps > Fibroblastic polyp of colon

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