Colon tumor
Lymphoma and hematopoietic lesions
Follicular lymphoma

Topic Completed: 1 February 2012

Revised: 12 June 2019

Copyright: 2003-2019,, Inc.

PubMed Search: "Follicular lymphoma" colon

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Cite this page: Singh C. Follicular lymphoma. website. Accessed November 20th, 2019.
Definition / general
  • See also Lymphoma and plasma cell neoplasms chapter
  • Rare in colon; more common in small intestine (Am J Pathol 1992;140:1327)
  • Resemble mucosal polyps
  • Histopathogenesis: primary gastrointestinal follicular lymphoma usually express immunoglobulin A (IgA) and α4β7 mucosal homing receptor, which suggests origin from intestinal antigen experienced B cells
Prognosis and treatment
  • Primary gastrointestinal follicular lymphoma tends to have indolent, low stage IE and IIE disease
  • Most patients can be followed by watchful waiting
Case reports
Microscopic (histologic) description
  • Similar to nodal follicular lymphoma; forms follicles with centrocytes and centroblasts
  • Usually grade 1, rarely grade 2 and 3
  • Precise grading may be difficult in small biopsy specimens
Microscopic (histologic) images

Images hosted on other servers:

Rectal tumor: left; CD20: upper right; bcl2: lower right

Positive stains
Negative stains
  • CD5, T cell markers (in tumor cells)
Molecular / cytogenetics description
  • bcl2-IgH translocation
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