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Table of Contents
Definition / general | Prognosis and treatment | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Molecular / cytogenetics descriptionCite this page: Follicular lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colontumorfollicular.html. Accessed July 14th, 2017.
Definition / general
- See also Lymphoma and plasma cell neoplasms chapter
- Rare in colon; more common in small intestine (Am J Pathol 1992;140:1327)
- Resemble mucosal polyps
- Histopathogenesis: primary gastrointestinal follicular lymphoma usually express immunoglobulin A (IgA) and α4β7 mucosal homing receptor, which suggests origin from intestinal antigen experienced B cells
Prognosis and treatment
- Primary gastrointestinal follicular lymphoma tends to have indolent, low stage IE and IIE disease
- Most patients can be followed by watchful waiting
Case reports
- 47 year old man with 10 cm tumor of splenic flexure (J Clin Oncol 1999;17:3684)
- 59 year old woman with rectal tumor (World J Gastroenterol 2004;10:2602)
Microscopic (histologic) description
- Similar to nodal follicular lymphoma; forms follicles with centrocytes and centroblasts
- Usually grade 1, rarely grade 2 and 3
- Precise grading may be difficult in small biopsy specimens
Microscopic (histologic) images
Images hosted on other servers:
Rectal tumor: left; CD20: upper right; bcl2: lower right
H&E
Left: CD20; right: bcl2
Negative stains
- CD5, T cell markers (in tumor cells)
Molecular / cytogenetics description
- bcl2-IgH translocation
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