Colon tumor
Lymphoma and hematopoietic lesions
Follicular lymphoma

Author: Charanjeet Singh, M.D. (see Authors page)

Revised: 3 January 2017, last major update February 2012

Copyright: (c) 2003-2017,, Inc.

PubMed Search: "Follicular lymphoma" colon

Cite this page: Follicular lymphoma. website. Accessed June 20th, 2018.
Definition / general
  • See also Lymphoma and plasma cell neoplasms chapter
  • Rare in colon; more common in small intestine (Am J Pathol 1992;140:1327)
  • Resemble mucosal polyps
  • Histopathogenesis: primary gastrointestinal follicular lymphoma usually express immunoglobulin A (IgA) and α4β7 mucosal homing receptor, which suggests origin from intestinal antigen experienced B cells
Prognosis and treatment
  • Primary gastrointestinal follicular lymphoma tends to have indolent, low stage IE and IIE disease
  • Most patients can be followed by watchful waiting
Case reports
Microscopic (histologic) description
  • Similar to nodal follicular lymphoma; forms follicles with centrocytes and centroblasts
  • Usually grade 1, rarely grade 2 and 3
  • Precise grading may be difficult in small biopsy specimens
Microscopic (histologic) images

Images hosted on other servers:

Rectal tumor: left; CD20: upper right; bcl2: lower right


Left: CD20; right: bcl2

Positive stains
Negative stains
  • CD5, T cell markers (in tumor cells)
Molecular / cytogenetics description
  • bcl2-IgH translocation