Histiocytic sarcoma of colon
Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 15 April 2012, last major update April 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Rare; many cases diagnosed without immunohistochemistry are actually lymphomas
● Mean age 55 years (range 15-89 years)
● Solitary mass, often involving regional lymph nodes
● Infiltrative margins
● Sheets of large epithelioid cells with abundant eosinophilic cytoplasm, oval to irregular nuclei, vesicular chromatin and prominent nucleoli
● Often binucleated or tumor giant cells
● Prominent inflammatory infiltrate
● Often mitotic activity and necrosis
Nuclear pleomorphism, mitotic activity and hemophagocytosis
Not necessarily colon:
Large epithelioid cells invading bone and exhibiting hemophagocytosis
● CD45 / LCA, CD45RO, CD68, CD4, lysozyme and CD31
● CD163 (Mod Pathol 2005;18:693)
● Variable S100, CD1a and CD30 (weak)
● ALK1, CD21, CD35, CD3, CD20, CD34, myeloperoxidase, HMB45, keratin, c-kit and desmin
● Am J Surg Pathol 2004;28:1133
End of Colon tumor > Mesenchymal tumors > Histiocytic sarcoma of colon
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