Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Colon tumor

Mesenchymal tumors

Histiocytic sarcoma of colon


Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 15 April 2012, last major update April 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Rare; many cases diagnosed without immunohistochemistry are actually lymphomas
● Mean age 55 years (range 15-89 years)

Gross description
=========================================================================

● Solitary mass, often involving regional lymph nodes
● Infiltrative margins

Micro description
=========================================================================

● Sheets of large epithelioid cells with abundant eosinophilic cytoplasm, oval to irregular nuclei, vesicular chromatin and prominent nucleoli
● Often binucleated or tumor giant cells
● Prominent inflammatory infiltrate
● Often mitotic activity and necrosis

Micro images
=========================================================================



Nuclear pleomorphism, mitotic activity and hemophagocytosis


Prominent spindling

Not necessarily colon:

Large epithelioid cells invading bone and exhibiting hemophagocytosis


Immunostains

Positive stains
=========================================================================

● CD45 / LCA, CD45RO, CD68, CD4, lysozyme and CD31
● CD163 (Mod Pathol 2005;18:693)
● Variable S100, CD1a and CD30 (weak)

Negative stains
=========================================================================

● ALK1, CD21, CD35, CD3, CD20, CD34, myeloperoxidase, HMB45, keratin, c-kit and desmin

Additional references
=========================================================================

Am J Surg Pathol 2004;28:1133

End of Colon tumor > Mesenchymal tumors > Histiocytic sarcoma of colon


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).