Colon tumor - Histiocytic sarcoma of colon

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Colon tumor

Mesenchymal tumors

Histiocytic sarcoma of colon

Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 15 April 2012, last major update April 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Rare; many cases diagnosed without immunohistochemistry are actually lymphomas
● Mean age 55 years (range 15-89 years)

Gross description
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● Solitary mass, often involving regional lymph nodes
● Infiltrative margins

Micro description
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● Sheets of large epithelioid cells with abundant eosinophilic cytoplasm, oval to irregular nuclei, vesicular chromatin and prominent nucleoli
● Often binucleated or tumor giant cells
● Prominent inflammatory infiltrate
● Often mitotic activity and necrosis

Micro images
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Nuclear pleomorphism, mitotic activity and hemophagocytosis

Prominent spindling

Not necessarily colon:

Large epithelioid cells invading bone and exhibiting hemophagocytosis

Immunostains

Positive stains
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● CD45 / LCA, CD45RO, CD68, CD4, lysozyme and CD31
● CD163 (Mod Pathol 2005;18:693)
● Variable S100, CD1a and CD30 (weak)

Negative stains
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● ALK1, CD21, CD35, CD3, CD20, CD34, myeloperoxidase, HMB45, keratin, c-kit and desmin

Additional references
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● Am J Surg Pathol 2004;28:1133

End of Colon tumor > Mesenchymal tumors > Histiocytic sarcoma of colon

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