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Colon tumor

Familial polyposis syndromes

Hyperplastic polyposis syndrome

Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 25 May 2012, last major update September 2011
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Uncommon
● Also called serrated adenomatous polyposis because polyps appear to be serrated adenomas
● WHO definition: (a) at least 5 histologically diagnosed hyperplastic polyps proximal to sigmoid colon, two of which are larger than 1 cm; or (b) any number of hyperplastic polyps proximal to sigmoid colon in patients with a first-degree relative with hyperplastic polyposis; or (c) more than 30 hyperplastic polyps of any size distributed throughout colorectum
● High risk for colorectal carcinoma (Dis Colon Rectum 2004;47:2101, Am J Surg Pathol 2001;25:177); regular surveillance is recommended (Am J Gastroenterol 2004;99:2012), including family members

Case reports

● Associated with two synchronous carcinomas (Am J Pathol 2000;157:385), inverted hyperplastic polyposis (J Clin Pathol 1993;46:56)

Gross description

● Polyps are usually sessile

Gross images

Inverted polyposis

Micro images

Inverted hyperplastic polyps


Associated with submucosal adipose

Large submucosal mucin cyst

With epithelial displacement to lymphoid follicle

CEA+ (normal colon at upper right is CEA negative)


● Extensive methylation in adenomas and in normal mucosa (Gut 2006;55:1467)

End of Colon tumor > Familial polyposis syndromes > Hyperplastic polyposis syndrome

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