Colon tumor - Inflammatory myofibroblastic tumor of colon

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Colon tumor

Mesenchymal tumors

Inflammatory myofibroblastic tumor of colon

Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 15 April 2012, last major update April 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Also called inflammatory pseudotumor, inflammatory fibrosarcoma and plasma cell granuloma
● Often a pediatric tumor, usually multifocal, associated with fever, weight loss, anemia, leukocytosis, thrombocytosis, high sedimentation rate and hypergammaglobulinemia (J Pediatr Surg 2001;36:169)
● Benign, but may recur

Case reports
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● 7 year old child (Croat Med J 1999;40:550)
● 11 year old boy (Archives of Iranian Medicine 2006;9:277)
● 35 year old woman with clinical appendicitis (Scott Med J 2004;49:157)
● 35 year old man (J Korean Surg Soc 2012;82:45)
● 69 year old man with incidental adenocarcinoma (Ann Ital Chir 1997;68:245)
● 71 year old woman with colonic obstruction (Surg Today 1998;28:416)

Gross description
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● Circumscribed

Clinical / gross images
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2 year old boy with colonic mass causing anemia

35 year old man with mass involving muscularis propria

Micro description
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● Spindle cells with abundant amphophilic cytoplasm
● Variably prominent nucleoli, lymphoplasmacytic infiltrate with polyclonal plasma cells
● Laminated or whorled fibrosis
● May contain psammoma bodies if present in peritoneum

Micro images
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Colonic mass

Not necessarily colon:

Inflammatory cells and spindle cells

Mesenteric mass

CD117 negative

Positive stains
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● Desmin, actin; variable ALK1

Negative stains
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● S100, CD117, CD34

Molecular description
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● Fluorescent in-situ hybridization for t(2:5) or variants

Electron microscopy description
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● Myofibroblasts

Differential diagnosis
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● Schistosomiasis (J Natl Med Assoc 2006;98:1365) or other inflammatory masses

End of Colon tumor > Mesenchymal tumors > Inflammatory myofibroblastic tumor of colon

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