Colon tumor
Inflammatory polyp of colon

Author: Jela Bandovic, M.D. (see Authors page)

Revised: 12 December 2016, last major update May 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: "Inflammatory polyp" colon

See Also: Giant inflammatory polyp / polyposis of colon, Inflammatory polyp of colon secondary to mucosal prolapse
Cite this page: Inflammatory polyp of colon. website. Accessed November 24th, 2017.
Definition / general
  • Inflamed regenerating mucosa surrounded by ulcerated tissue; also granulation tissue overlying epithelium
  • Associated with Crohn's disease or ulcerative colitis; also amebiasis, schistosomiasis, ulcer and anastomotic sites
  • Usually asymptomatic but may cause obstruction or hemorrhage
  • Benign; no increased risk of dysplasia compared to surrounding mucosa, although patients with inflammatory polyposis, due to ulcerative colitis, have an increased risk of dysplasia, usually in flat lesions
Case reports
  • Treat underlying inflammatory condition
Gross description
  • Smooth hyperemic or hypervascular appearance; variable surface erosion
Gross images

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Inflammatory pseudopolyps in ulcerative colitis

Microscopic (histologic) description
  • Inflamed lamina propria and distorted colonic epithelium (branched, tortuous, elongated or cystic crypts)
  • May have surface erosion, congestion / hemorrhage or crypt abscesses
  • May have bizarre stromal changes in reactive fibroblasts resembling sarcoma in a fibroblastic or granulation tissue stroma, particularly underneath areas of ulceration
  • No / few mitotic figures, no atypical mitotic figures and often zonation
Microscopic (histologic) images

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Ulcerative colitis

Annotated images

Positive stains
Negative stains
Differential diagnosis