Colon tumor - Inflammatory fibroid polyp

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Colon tumor

Polyps

Inflammatory fibroid polyp

Reviewers: Jela Bandovic, M.D. (see Reviewers page)
Revised: 25 May 2012, last major update May 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Uncommon in colon
● Any age, no clinical associations
● Benign

Case reports
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● 40 year old man with positive fecal occult blood test (Dig Liver Dis 2005;37:968)
● 66 year old woman with neurofibromatosis (Ann Acad Med Singapore 2004;33:797)
● Causing intussusception (Dis Colon Rectum 1979;22:575)

Treatment
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● Endoscopic excision if small (Intern Med 2000;39:25)
● Resection if large

Gross description
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● Mean 3-4 cm, polypoid with broad base
● Tan-gray-yellow; overlying mucosa may be ulcerated

Gross images
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Small bowel

Micro description
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● Usually limited to submucosa
● Spindle cell lesion in fibrovascular stroma with chronic inflammatory infiltrate including eosinophils
● May be sparsely cellular with myxoid stroma
● Cellular areas may have up to 2 mitotic figures / HPF
● May have rarefaction (zone of loose connective tissue) around muscular-walled blood vessels

Micro images
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Small bowel

Figure 3

Positive stains
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● Vimentin, muscle specific actin, smooth muscle actin and CD34
● Variable S100

Negative stains
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● Desmin, CD117

Differential diagnosis
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● Fibromatosis: invades bowel secondarily
● Arteriovenous malformation (J Gastroenter 2004;39:575)

End of Colon tumor > Polyps > Inflammatory fibroid polyp

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