Intramucosal carcinoma of colon
Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 15 October 2011, last major update September 2011
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● Malignant change confined to mucosa; for adenomas, no invasion into submucosal stalk, no undifferentiated carcinoma, no vascular invasion and no desmoplastic stroma
● Stage Tis
● Some of these lesions are also called small flat carcinomas
● Controversial terminology - may reflect differing thresholds for malignancy between West (higher threshold) and Japan (lower threshold), as Japanese pathologists diagnose as malignant what West calls high grade dysplastic lesions
● Rosai suggests calling these lesions polyps with severe atypia
● Little metastatic potential as there are minimal lymphatic channels in colonic mucosa, so resection is not indicated (endoscopic mucosal resections have been tried for this category of tumors, Endoscopy 2006;38:231)
● If tumor invades stalk of polyp, then bowel resection may be justified
● Juvenile polyp with intramucosal carcinoma (Arch Pathol Lab Med 1987;111:200)
End of Colon tumor > Carcinoma > Intramucosal carcinoma of colon
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