Intramucosal carcinoma of colon

Colon tumor
Carcinoma
Intramucosal carcinoma of colon

Author: Raul Gonzalez M.D. (see Authors page)

Revised: 27 December 2016, last major update September 2015

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: "Intramucosal carcinoma" colon

Table of Contents

Cite this page: Intramucosal carcinoma of colon. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colontumorintramucosal.html. Accessed July 14th, 2017.

Definition / general

Malignant change confined to mucosa (considered pTis in AJCC staging)

Proper cutoff between high grade dysplasia and intramucosal carcinoma is not entirely clear

Terminology

Controversial term that reflects differing thresholds for malignancy between the West (higher threshold) and Japan (lower threshold), as Japanese pathologists often diagnose as malignant what Western pathologists might call high grade dysplasia

Clinical features

Up to 2% of cases may metastasize to lymph nodes (J Clin Oncol 2010;28:e469); earlier theory that colonic mucosa has no lymphatic channels may be erroneous (Histopathology 2015;67:167)

Intramucosal carcinoma on biopsy may portend unsampled invasive disease (Ann Surg Oncol 2009;16:3267)

Case reports

51 year old man with sporadic juvenile polyp of the colon harboring an intramucosal adenocarcinoma (Int J Surg Pathol 2015;23:571)

71 year old man with TisN0M1 sigmoid colon cancer (Ann Coloproctol 2014;30:141)

Treatment

Polypectomy should be sufficient for "intramucosal carcinoma" confined to a polyp, even with a poorly differentiated component (Am J Surg Pathol 2007;31:1882)

Endoscopic mucosal resection may be curative (J Gastroenterol Hepatol 2011;26:1619)

Clinical images

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