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Colon tumor

Mesenchymal tumors

Idiopathic retroperitoneal fibrosis of colon


Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 15 April 2012, last major update April 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Also called Ormond’s disease
● Fibrosis develops in retroperitoneum, often at aortic bifurcation
● Associated with methylsergine, lymphoma, other fibrotic lesions (sclerosis of major bile ducts, Riedel’s thyroiditis, inflammatory pseudotumor of orbit) and tumors as a paraneoplastic process (Acta Med Austriaca 2000;27:168)

Case reports
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● 39 year old woman with obstruction (Ann Surg 1972;176:199)

Gross description
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● Not well-circumscribed

Micro description
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● Widely scattered germinal centers and plasma cells in background of dense fibrosis
● May have fat necrosis

Micro images
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Diffuse fibrosis infiltrating adipose, also fat necrosis


Involving ureters

Differential diagnosis
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Whipple’s disease: lipogranulomatous inflammation with large, round and empty spaces containing PAS+ bacilli

Additional references
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eMedicine

End of Colon tumor > Mesenchymal tumors > Idiopathic retroperitoneal fibrosis of colon


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