Colon tumor - Kaposi’s sarcoma of colon

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Colon tumor

Mesenchymal tumors

Kaposi’s sarcoma of colon

Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 16 May 2012, last major update May 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● GI involvement in 50-80% with visceral involvement due to AIDS or in endemic areas of Africa
● GI symptoms are rare (diarrhea, protein-losing enteropathy and abdominal pain)

Case reports
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● 36 year old HIV negative woman with Crohn’s disease (Dig Dis Sci 1991;36:528)
● 87 year old man with coexisting colon cancer (Acta Dermatovenerol Alp Panonica Adriat 2011;20:83)
● HIV negative man #1 (J Surg Oncol 2001;76:197), #2 with ulcerative colitis (Dis Colon Rectum 1989;32:73)

Clinical images
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Kaposi sarcoma

Gross description
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● Red-brown to purple macules or nodules 5-15 mm

Micro description
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● Submucosal lesions similar to skin lesions
● Expansion of lamina propria by spindle cells with mild / moderate atypia that obliterate muscularis mucosa
● Extravasated red blood cells common

Micro images
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Kaposi's sarcoma

Low power, high power #1, #2, CD34

Positive stains
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● CD31, CD34; CD117 (focal in 15%)

Negative stains
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● S100, desmin, muscle specific actin and HMB45

Differential diagnosis
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● GIST
● Melanoma

End of Colon tumor > Mesenchymal tumors > Kaposi’s sarcoma of colon

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