Colon tumor
Mesenchymal tumors

Author: Raul S. Gonzalez, M.D. (see Authors page)

Revised: 3 March 2017, last major update February 2017

Copyright: (c) 2003-2017,, Inc.

PubMed search: leiomyomatosis colon

Cite this page: Leiomyomatosis. website. Accessed March 29th, 2017.
Definition / General
  • Multiple leiomyomas arising in the colonic muscularis propria
Essential Features
  • Extremely rare multifocal mesenchymal process in the colon
  • Arises in the muscularis propria, whereas sporadic colonic leiomyomas arise in the muscularis mucosae
  • Esophagus is most common site of gastrointestinal leiomyomatosis
Clinical Features
  • May cause abdominal pain or obstruction
Case Reports
Clinical Images

Images hosted on other servers:

peritonealis disseminata
involving colon (C, D)

Gross Description
  • Multifocal tumor masses in muscular layer
Micro Description
  • Proliferating nodules of benign smooth muscle cells arising in muscularis propria (leiomyomatosis) or studding serosa / mesentery (leiomyomatosis peritonealis disseminata)
  • Tumors have no atypia and rare to no mitotic figures
Positive Stains
Negative Stains
Differential Diagnosis