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Table of Contents
Definition / general | Essential features | Terminology | Sites | Clinical features | Case reports | Clinical images | Gross description | Microscopic (histologic) description | Positive stains | Negative stains | Differential diagnosisCite this page: Leiomyomatosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colontumorleiomyomatosis.html. Accessed July 14th, 2017.
Definition / general
- Multiple leiomyomas arising in the colonic muscularis propria
Essential features
- Extremely rare multifocal mesenchymal process in the colon
- Arises in the muscularis propria, whereas sporadic colonic leiomyomas arise in the muscularis mucosae
Terminology
- Includes leiomyomatosis, leiomyomatosis peritonealis disseminata and leiomyomatosis-like lymphangioleiomyomatosis
Sites
- Esophagus is most common site of gastrointestinal leiomyomatosis
Clinical features
- May cause abdominal pain or obstruction
Case reports
- 30 year old female with leiomyomatosis involving 40 cm of colon (Cancer 1977;39:263)
- 35 year old man with leiomyomatosis involving colon and mesentery (Am J Gastroenterol 1986;81:385)
- Leiomyomatosis involving small intestine and colon (Arch Pathol Lab Med 1992;116:281)
Clinical images
Images hosted on other servers:
Leiomyomatosis
peritonealis disseminata
involving colon (C, D)
Gross description
- Multifocal tumor masses in muscular layer
Microscopic (histologic) description
- Proliferating nodules of benign smooth muscle cells arising in muscularis propria (leiomyomatosis) or studding serosa / mesentery (leiomyomatosis peritonealis disseminata)
- Tumors have no atypia and rare to no mitotic figures
Positive stains
Differential diagnosis
- Leiomyoma: single, sporadic; arises in muscularis mucosae
- Leiomyomatosis-like lymphangioleiomyomatosis: arises in tuberous sclerosis; tumors are HMB45 positive
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