Colon tumor
Mesenchymal tumors

Author: Raul S. Gonzalez, M.D. (see Authors page)

Revised: 3 March 2017, last major update February 2017

Copyright: (c) 2003-2017,, Inc.

PubMed search: leiomyomatosis colon

Cite this page: Leiomyomatosis. website. Accessed June 20th, 2018.
Definition / general
  • Multiple leiomyomas arising in the colonic muscularis propria
Essential features
  • Extremely rare multifocal mesenchymal process in the colon
  • Arises in the muscularis propria, whereas sporadic colonic leiomyomas arise in the muscularis mucosae
  • Esophagus is most common site of gastrointestinal leiomyomatosis
Clinical features
  • May cause abdominal pain or obstruction
Case reports
Clinical images

Images hosted on other servers:

peritonealis disseminata
involving colon (C, D)

Gross description
  • Multifocal tumor masses in muscular layer
Microscopic (histologic) description
  • Proliferating nodules of benign smooth muscle cells arising in muscularis propria (leiomyomatosis) or studding serosa / mesentery (leiomyomatosis peritonealis disseminata)
  • Tumors have no atypia and rare to no mitotic figures
Positive stains
Negative stains
Differential diagnosis