Colon tumor
Mesenchymal tumors

Topic Completed: 1 February 2017

Revised: 9 July 2019

Copyright: 2003-2019,, Inc.

PubMed search: leiomyomatosis colon

Raul S. Gonzalez, M.D.
Page views in 2018: 384
Page views in 2019 to date: 442
Cite this page: Gonzalez R. Leiomyomatosis. website. Accessed December 7th, 2019.
Definition / general
  • Multiple leiomyomas arising in the colonic muscularis propria
Essential features
  • Extremely rare multifocal mesenchymal process in the colon
  • Arises in the muscularis propria, whereas sporadic colonic leiomyomas arise in the muscularis mucosae
  • Esophagus is most common site of gastrointestinal leiomyomatosis
Clinical features
  • May cause abdominal pain or obstruction
Case reports
Clinical images

Images hosted on other servers:

involving colon (C, D)

Gross description
  • Multifocal tumor masses in muscular layer
Microscopic (histologic) description
  • Proliferating nodules of benign smooth muscle cells arising in muscularis propria (leiomyomatosis) or studding serosa / mesentery (leiomyomatosis peritonealis disseminata)
  • Tumors have no atypia and rare to no mitotic figures
Positive stains
Negative stains
Differential diagnosis
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