Colon tumor
Mesenchymal tumors

Topic Completed: 1 May 2017

Minor changes: 12 June 2019

Copyright::2003-2019,, Inc.

PubMed search: lipoma [title] colon

Raul S. Gonzalez, M.D.
Page views in 2019: 3,474
Page views in 2020 to date: 1,491
Cite this page: Gonzalez R. Lipoma. website. Accessed July 13th, 2020.
Definition / general
  • Benign colonic neoplasm composed of mature adipose tissue
Essential features
  • Most common submucosal mesenchymal lesion of colon
  • Typically small and benign, but can cause symptoms if large
  • Usually submucosal in right colon
Clinical features
Case reports
Gross description
  • Soft, yellow cut surface
  • Size can vary; large lesions may have overlying ulceration
Gross images

Images hosted on other servers:

Large pedunculated submucosal tumor

Cut section of tumor

Microscopic (histologic) description
  • Benign, well circumscibed (but not encapsulated) adipose tissue, usually in the submucosa
  • Overlying mucosa usually normal but may show an adenoma or a serrated polyp (World J Clin Cases 2013;1:124)
  • May have overlying mucosal ulceration, atypical stromal cells and florid vascular proliferation due to repeated intussusception (Pathol Int 2005;55:160)
Microscopic (histologic) images

Contributed by Raul S. Gonzalez, M.D:

Large lipoma with overlying ulceration

Images hosted on other servers:

Lipoma with overlying sessile serrated adenoma

Differential diagnosis
  • Lipomatous hypertrophy of ileocecal valve: also benign; not well circumscribed
Board review style question #1
Benign fatty lesions of the colon usually arise in what layer of the wall?

  1. Lamina propria
  2. Muscularis mucosae
  3. Muscularis propria
  4. Submucosa
  5. Subserosa
Board review answer #1
D. Submucosa

Reference: Colon tumor - Lipoma

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