Colon tumor
Mesenchymal tumors

Topic Completed: 1 May 2017

Revised: 15 January 2019, last major update May 2017

Copyright: (c) 2003-2017,, Inc.

PubMed search: lipoma [title] colon

Page views in 2018: 3,136
Page views in 2019 to date: 1,410
Cite this page: Gonzalez R. Lipoma. website. Accessed May 21st, 2019.
Definition / general
  • Benign colonic neoplasm composed of mature adipose tissue
Essential features
  • Most common submucosal mesenchymal lesion of colon
  • Typically small and benign, but can cause symptoms if large
  • Usually submucosal in right colon
Clinical features
Case reports
Gross description
  • Soft, yellow cut surface
  • Size can vary; large lesions may have overlying ulceration
Gross images

Images hosted on other servers:

Large pedunculated submucosal tumor

Cut section of tumor

Microscopic (histologic) description
  • Benign, well circumscibed (but not encapsulated) adipose tissue, usually in the submucosa
  • Overlying mucosa usually normal but may show an adenoma or a serrated polyp (World J Clin Cases 2013;1:124)
  • May have overlying mucosal ulceration, atypical stromal cells and florid vascular proliferation due to repeated intussusception (Pathol Int 2005;55:160)
Microscopic (histologic) images

Images hosted on PathOut server, courtesy of Raul S. Gonzalez, M.D:

Large lipoma with overlying ulceration

Images hosted on other servers:

Lipoma with overlying sessile serrated adenoma

Differential diagnosis
  • Lipomatous hypertrophy of ileocecal valve: also benign; not well circumscribed
Board review question #1
Benign fatty lesions of the colon usually arise in what layer of the wall?

A. Lamina propria
B. Muscularis mucosae
C. Muscularis propria
D. Submucosa
E. Subserosa
Board review answer #1
D. Submucosa
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