Colon tumor
Mesenchymal tumors

Topic Completed: 1 May 2017

Revised: 15 January 2019, last major update May 2017

Copyright: (c) 2003-2017,, Inc.

PubMed Search: Colonic liposarcoma
Page views in 2018: 310
Page views in 2019 to date: 103
Cite this page: Gonzalez R. Liposarcoma. website. Accessed May 21st, 2019.
Definition / general
  • Rare adipocytic sarcoma primarily or secondarily involving the colon
Essential features
  • Rare and usually arises in the retroperitoneum or mesentery
  • Can be any subtype of liposarcoma
  • Soft tissue terminology applies for tumor subtypes (well differentiated liposarcoma, myxoid liposarcoma, etc.)
  • Frequently arises in retroperitoneum, involving colon secondarily
Clinical features
  • Occurs across a wide age range
  • May cause abdominal pain or intussusception
Case reports
  • Resection, radiotherapy
Clinical images
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CT of liposarcoma filling abdomen

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Submucosal liposarcoma on colonoscopy

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Liposarcoma removal during surgery

Gross description
  • Large mass that can involve other organs in addition to the colon
Gross images
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Tumor of pericolonic adipose tissue

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Tumor replacing colon wall

Microscopic (histologic) description
  • Various subtypes; see soft tissue section for additional information
  • Dedifferentiated liposarcomas may resemble other mesenchymal tumors (such as GIST) but usually have foci of well differentiated liposarcoma
Microscopic (histologic) images
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Well differentiated and dedifferentiated liposarcomas, by Raul S. Gonzalez, M.D.

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Well differentiated liposarcoma

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Mixed-type liposarcoma

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Dedifferentiated liposarcoma

Positive stains
Board review question #1
    Liposarcomas involving the gastrointestinal tract usually arise in what location?

  1. Extragastrointestinal
  2. Mucosa
  3. Muscularis propria
  4. Submucosa
  5. Subserosa
Board review answer #1
A. Extragastrointestinal
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