Topic Completed: 1 May 2015

Minor changes: 1 October 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Micropapillary carcinoma [title] colon

Raul S. Gonzalez, M.D.
Page views in 2019: 1,066
Page views in 2020 to date: 1,186
Cite this page: Gonzalez R. Micropapillary. website. Accessed November 25th, 2020.
Definition / general
  • Uncommon subtype of colonic adenocarcinoma with distinctive behavior
  • Officially recognized in WHO classification
Case reports
Microscopic (histologic) description
  • Small clusters of malignant cells with abundant eosinophilic cytoplasm and pleomorphic nuclei
  • Micropapillae inhabit lacunar-like spaces and demonstrate a "reverse polarity" configuration, with apical surfaces facing the periphery rather than the center
  • Lymphovascular invasion is commonly present
  • Morphology is similar to micropapillary carcinomas of other organs (Adv Anat Pathol 2004;11:297)
  • Coexisting regions of conventional adenocarcinoma also usually present
Microscopic (histologic) images

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Invasive micropapillae in lacunar-like spaces

Lymph node metastasis

Characteristic morphology and MUC1 immunostaining pattern

Positive stains
Molecular / cytogenetics description
Differential diagnosis
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