Colon tumor
Micropapillary carcinoma

Author: Raul Gonzalez M.D. (see Authors page)

Revised: 3 January 2017, last major update May 2015

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Micropapillary carcinoma [title] colon

Cite this page: Micropapillary carcinoma. website. Accessed July 21st, 2018.
Definition / general
  • Uncommon subtype of colonic adenocarcinoma with distinctive behavior
  • Officially recognized in WHO classification
Case reports
Microscopic (histologic) description
  • Small clusters of malignant cells with abundant eosinophilic cytoplasm and pleomorphic nuclei
  • Micropapillae inhabit lacunar-like spaces and demonstrate a "reverse polarity" configuration, with apical surfaces facing the periphery rather than the center
  • Lymphovascular invasion is commonly present
  • Morphology is similar to micropapillary carcinomas of other organs (Adv Anat Pathol 2004;11:297)
  • Coexisting regions of conventional adenocarcinoma also usually present
Microscopic (histologic) images

Images hosted on other servers:

Invasive micropapillae in lacunar-like spaces

Lymph node metastasis

Characteristic morphology and MUC1 immunostaining pattern

Positive stains
Molecular / cytogenetics description
Differential diagnosis