Colon (tumor & nontumor)
Mesenchymal tumors
Mucosal Schwann cell hamartoma

Topic Completed: 1 June 2016

Minor changes: 31 July 2020

Copyright: 2002-2019,, Inc.

PubMed Search: Mucosal Schwann cell hamartoma

Raul S. Gonzalez, M.D.
Page views in 2019: 4,743
Page views in 2020 to date: 2,529
Cite this page: Gonzalez R. Mucosal Schwann cell hamartoma. website. Accessed August 6th, 2020.
Definition / general
  • Benign mucosal proliferation composed of Schwann cells
Essential features
  • Benign, incidental spindle cell lesion
  • Not associated with any clinical syndrome
  • Positive for S100, negative for EMA
  • Has been called "neuroma" or "neurofibroma" in past
  • Can arise anywhere in the colorectum, but more common distally
Clinical features
  • Average patient age is 62 years, with a female predominance (Am J Surg Pathol 2009;33:781)
  • Not associated with any particular syndrome
  • Lesions do not recur
  • Discovered incidentally during colonoscopy
Case reports
Clinical images

Images hosted on other servers:

Rectal polyps on colonoscopy

Gross description
  • Small (6 mm or less) sessile polyp
Microscopic (histologic) description
  • Poorly circumscribed mucosal proliferation of spindle cells, with no whorling, no palisading, no fasciculation
  • Nuclei are generally small, bland and elongated
Microscopic (histologic) images

Contributed by Raul Gonzalez, M.D.

Various images

Images hosted on other servers:

Low power view on H&E

S100 positivity

Two rectal lesions (H&E and S100)

Positive stains
Differential diagnosis
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