Colon tumor
Neuroendocrine carcinoma

Topic Completed: 1 June 2015

Revised: 14 January 2019, last major update June 2015

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Neuroendocrine carcinoma [title] colon
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Cite this page: Gonzalez R. Neuroendocrine carcinoma. website. Accessed May 21st, 2019.
Definition / general
  • Two types, based on morphology: large cell neuroendocrine carcinoma (discussed herein) and small cell carcinoma (discussed here)
  • Disease typically presents at advanced stage, in patients often younger than those with colorectal adenocarcinoma (Dis Colon Rectum 2004;47:163)
  • Can arise anywhere along the colon or rectum
Prognostic factors
  • Good prognostic factors include peritumoral lymphocytes, microsatellite instability and pure large cell features; poor prognostic factors include CD117 positivity and vascular invasion (Am J Surg Pathol 2012;36:601)
Clinical images

Images hosted on other servers:

Rectal mass

Noncontrast CT scans of abdomen

Microscopic (histologic) description
  • Organoid arrangement of cells larger than those in small cell carcinoma, with nuclear pleomorphism and hyperchromasia, prominent nucleoli, numerous mitoses and tumor necrosis
Microscopic (histologic) images

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H&E, synaptophysin, chromogranin, Ki67

Large cell neuroendocrine carcinoma

ChromograninA, CK20

Ampulla of vater


Positive stains
Differential diagnosis
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