Colon tumor
Neuroendocrine carcinoma

Author: Raul Gonzalez M.D. (see Authors page)

Revised: 3 January 2017, last major update June 2015

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Neuroendocrine carcinoma [title] colon
Cite this page: Neuroendocrine carcinoma. website. Accessed April 27th, 2017.
Definition / General
  • Two types, based on morphology: large cell neuroendocrine carcinoma (discussed herein) and small cell carcinoma (discussed here)
  • Disease typically presents at advanced stage, in patients often younger than those with colorectal adenocarcinoma (Dis Colon Rectum 2004;47:163)
  • Can arise anywhere along the colon or rectum
Prognostic Factors
  • Good prognostic factors include peritumoral lymphocytes, microsatellite instability and pure large cell features; poor prognostic factors include CD117 positivity and vascular invasion (Am J Surg Pathol 2012;36:601)
Clinical Images

Images hosted on other servers:

Rectal mass

Noncontrast CT scans of abdomen

Micro Description
  • Organoid arrangement of cells larger than those in small cell carcinoma, with nuclear pleomorphism and hyperchromasia, prominent nucleoli, numerous mitoses and tumor necrosis
Micro Images

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H&E, synaptophysin, chromogranin, Ki67

Large cell neuroendocrine carcinoma

ChromograninA, CK20

Ampulla of vater


Positive Stains
Differential Diagnosis