Colon tumor
Carcinoma
Large cell neuroendocrine carcinoma


Topic Completed: 1 June 2015

Revised: 21 June 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Neuroendocrine carcinoma [title] colon

Raul S. Gonzalez, M.D.
Page views in 2018: 7,236
Page views in 2019 to date: 3,901
Cite this page: Gonzalez R. Large cell neuroendocrine carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colontumorneuroendocrine.html. Accessed July 18th, 2019.
Definition / general
Terminology
  • Two types, based on morphology: large cell neuroendocrine carcinoma (discussed herein) and small cell carcinoma (discussed here)
Epidemiology
  • Disease typically presents at advanced stage, in patients often younger than those with colorectal adenocarcinoma (Dis Colon Rectum 2004;47:163)
Sites
  • Can arise anywhere along the colon or rectum
Radiology images

Images hosted on other servers:

Rectal mass

Noncontrast CT scans of abdomen

Prognostic factors
  • Good prognostic factors include peritumoral lymphocytes, microsatellite instability and pure large cell features; poor prognostic factors include CD117 positivity and vascular invasion (Am J Surg Pathol 2012;36:601)
Microscopic (histologic) description
  • Organoid arrangement of cells larger than those in small cell carcinoma, with nuclear pleomorphism and hyperchromasia, prominent nucleoli, numerous mitoses and tumor necrosis
Microscopic (histologic) images

Images hosted on other servers:

H&E, synaptophysin, chromogranin, Ki67

Large cell neuroendocrine carcinoma

ChromograninA, CK20

Ampulla of vater

Cervix

Positive stains
Differential diagnosis
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