Colon tumor
Neuroendocrine neoplasms
Large cell neuroendocrine carcinoma

Topic Completed: 1 June 2015

Revised: 17 September 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Neuroendocrine carcinoma [title] colon

Raul S. Gonzalez, M.D.
Page views in 2018: 7,236
Page views in 2019 to date: 4,771
Cite this page: Gonzalez R. Large cell neuroendocrine carcinoma. website. Accessed September 17th, 2019.
Definition / general
  • Two types, based on morphology: large cell neuroendocrine carcinoma (discussed herein) and small cell carcinoma (discussed here)
  • Disease typically presents at advanced stage, in patients often younger than those with colorectal adenocarcinoma (Dis Colon Rectum 2004;47:163)
  • Can arise anywhere along the colon or rectum
Radiology images

Images hosted on other servers:

Rectal mass

Noncontrast CT scans of abdomen

Prognostic factors
  • Good prognostic factors include peritumoral lymphocytes, microsatellite instability and pure large cell features; poor prognostic factors include CD117 positivity and vascular invasion (Am J Surg Pathol 2012;36:601)
Microscopic (histologic) description
  • Organoid arrangement of cells larger than those in small cell carcinoma, with nuclear pleomorphism and hyperchromasia, prominent nucleoli, numerous mitoses and tumor necrosis
Microscopic (histologic) images

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H&E, synaptophysin, chromogranin, Ki67

Large cell neuroendocrine carcinoma

ChromograninA, CK20

Ampulla of vater


Positive stains
Differential diagnosis
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