Colon tumor - Perineurioma of colon

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Colon tumor

Mesenchymal tumors

Perineurioma of colon

Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 16 May 2012, last major update May 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Uncommon in GI tract
● Usually women, mean age 51 years (range 35-72 years)
● Benign, does not recur

Gross description
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● Small sessile polyp detected during colonoscopy, usually mucosal or submucosal in distal colon
● Median 0.4 cm

Micro description
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● Bland spindle cells with pale indistinct cytoplasm, ovoid nuclei and fine collagenous stroma
● No atypia, no pleomorphism and no mitotic figures
● Adjacent mucosa may have hyperplastic changes

Micro images
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Perineal tumor - H&E and EMA

Positive stains
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● EMA, variable claudin1 and CD34

Negative stains
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● S100, GFAP, neurofilament, smooth muscle actin, desmin, KIT and keratin

Electron microscopy description
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● Spindle cells with long bipolar cytoplasmic processes, prominent pinocytotic vesicle and discontinuous basal lamina

Differential diagnosis
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● Neurofibroma, solitary fibrous tumor

Additional references
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● Am J Surg Pathol 2005;29:859

End of Colon tumor > Mesenchymal tumors > Perineurioma of colon

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