Colon tumor - Post-treatment changes of colonic carcinoma

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Colon tumor

Carcinoma

Post-treatment changes of colonic carcinoma

Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 15 October 2011, last major update September 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

Definition
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● Preoperative (neoadjuvant) radiation therapy, with or without chemotherapy, is often used to treat rectal adenocarcinoma
● Presence of acellular mucin reflects pretreatment tumor

Gross description
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● Flat, firm mass with central ulceration
● May be no identifiable lesion

Micro description
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● Regenerated mucosa at edge of ulcer
● Tumor cells with variable tumor effects of fibrosis, mucin pools, inflammation and necrosis

Positive stains
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● Cytokeratin to detect rare residual tumor cells

End of Colon tumor > Carcinoma > Post-treatment changes of colonic carcinoma

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