Colon tumor
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Rosai-Dorfman disease

Author: Charanjeet Singh, M.D. (see Authors page)

Revised: 4 January 2017, last major update May 2012

Copyright: (c) 2003-2017,, Inc.

PubMed search: Rosai-Dorfman colon

Cite this page: Rosai-Dorfman disease. website. Accessed April 23rd, 2017.
Definition / General
  • Extranodal form of sinus histiocytosis with massive lymphadenopathy
  • Rare in colon; < 15 cases reported through May 2012, usually incidental or at autopsy
  • Polyclonal / reactive; usually has protracted clinical course
Case Reports
Clinical Images

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Gross Description
  • Round mass with intact overlying mucosa
Micro Description
  • Sheets of large foamy histiocytes without nuclear grooves, mixed with lymphocytes and plasma cells
  • Histiocytes infiltrate submucosa and muscularis propria but not mucosa
  • Histiocytes demonstrate emperipolesis (ingestion of red blood cells)
  • Lymph nodes have similar findings
Micro Images

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Large pale histiocytes with emperipolesis

Positive Stains
Negative Stains
Differential Diagnosis