Colon tumor
Other tumors
Rosai-Dorfman disease

Topic Completed: 1 May 2012

Revised: 12 June 2019

Copyright: 2003-2019,, Inc.

PubMed search: Rosai-Dorfman colon

Page views in 2018: 293
Page views in 2019 to date: 411
Cite this page: Singh C. Rosai-Dorfman disease. website. Accessed November 20th, 2019.
Definition / general
  • Extranodal form of sinus histiocytosis with massive lymphadenopathy
  • Rare in colon; < 15 cases reported through May 2012, usually incidental or at autopsy
  • Polyclonal / reactive; usually has protracted clinical course
Case reports
Clinical images

Images hosted on other servers:


Gross description
  • Round mass with intact overlying mucosa
Microscopic (histologic) description
  • Sheets of large foamy histiocytes without nuclear grooves, mixed with lymphocytes and plasma cells
  • Histiocytes infiltrate submucosa and muscularis propria but not mucosa
  • Histiocytes demonstrate emperipolesis (ingestion of red blood cells)
  • Lymph nodes have similar findings
Microscopic (histologic) images

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Large pale histiocytes with emperipolesis

Positive stains
Negative stains
Differential diagnosis
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