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Colon tumor

Other tumors

Rosai-Dorfman disease of colon


Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 2 May 2012, last major update May 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Extranodal form of sinus histiocytosis with massive lymphadenopathy
● Rare in colon, < 15 cases reported thru May 2012, usually incidental or at autopsy
● Polyclonal / reactive; usually has protracted clinical course

Case reports
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● 51 year old woman with intermittent hematochezia (Arch Pathol Lab Med 2003;127:E74)
● 62 year old woman with unexplained peritonitis (Rare Tumors 2010;2:e2)

Clinical images
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Endoscopy

Gross description
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● Round mass with intact overlying mucosa

Micro description
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● Sheets of large foamy histiocytes without nuclear grooves, mixed with lymphocytes and plasma cells
● Histiocytes infiltrate submucosa and muscularis propria but not mucosa
● Histiocytes demonstrate emperipolesis (ingestion of red blood cells)
● Lymph nodes have similar findings

Micro images
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Large pale histiocytes with emperipolesis

Positive stains
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● Histiocytes: S100, lysozyme and CD68

Negative stains
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● Histiocytes: CD1a

Differential diagnosis
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Langerhans cell histiocytosis: grooved nuclei, CD1a+

End of Colon tumor > Other tumors > Rosai-Dorfman disease of colon


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