Rosai-Dorfman disease

Colon tumor
Other tumors
Rosai-Dorfman disease

Author: Charanjeet Singh, M.D. (see Authors page)

Revised: 4 January 2017, last major update May 2012

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed search: Rosai-Dorfman colon

Table of Contents

Cite this page: Rosai-Dorfman disease. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colontumorrosaidorf.html. Accessed July 14th, 2017.

Definition / general

Extranodal form of sinus histiocytosis with massive lymphadenopathy
Rare in colon; < 15 cases reported through May 2012, usually incidental or at autopsy
Polyclonal / reactive; usually has protracted clinical course

Case reports

51 year old woman with intermittent hematochezia (Arch Pathol Lab Med 2003;127:E74)
62 year old woman with unexplained peritonitis (Rare Tumors 2010;2:e2)

Clinical images

Images hosted on other servers:

Endoscopy

Gross description

Round mass with intact overlying mucosa

Microscopic (histologic) description

Sheets of large foamy histiocytes without nuclear grooves, mixed with lymphocytes and plasma cells
Histiocytes infiltrate submucosa and muscularis propria but not mucosa
Histiocytes demonstrate emperipolesis (ingestion of red blood cells)
Lymph nodes have similar findings

Microscopic (histologic) images

Images hosted on other servers:

Large pale histiocytes with emperipolesis

Positive stains

Histiocytes: S100, lysozyme and CD68

Negative stains

Histiocytes: CD1a

Differential diagnosis

Langerhans cell histiocytosis: grooved nuclei, CD1a+