Home   Chapter Home   Jobs   Conferences   Fellowships   Books


Colon tumor


Squamous cell carcinoma of colon

Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 25 February 2012, last major update January 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Extremely rare
● Diagnosis of primary colonic tumor requires no involvement of cloacogenic or squamous lined mucosa, no squamous cell carcinoma elsewhere in body and generous sampling to exclude adenosquamous carcinoma (Surg Today 1994;24:75)
● Associated with ulcerative colitis (J Surg Oncol 1995;59:48), radiation therapy and schistosomiasis
● Aggressive (Saudi Med J 2006;27:874); often metastatic to liver, peritoneum or lung
● Favorable survival if node negative at presentation (Dis Colon Rectum 2001;44:341)
● May cause hypercalcemia (Dig Surg 2005;22:371)

Case reports

● 54 year old man with elevated serum squamous cell carcinoma antigen (Clin Colorectal Cancer 2001;1:55)
● 59 year old woman with acantholytic variant of squamous carcinoma of cecum (Diagn Pathol 2011;6:5)
● 60 year old woman with colocutaneous fistula (World J Gastroenterol 2005;11:5251)
● In colon duplication (Cancer 1981;47:602)
● In villous adenoma (Hum Pathol 1988;19:362)

Micro images

Primary Squamous cell carcinoma of cecum

Negative stains

● HPV (Eur J Surg Oncol 2002;28:657)

Differential diagnosis

● Extension or metastasis from anal or other carcinomas: Eur J Cardiothorac Surg 2001;19:719
Adenosquamous carcinoma: malignant glandular component with mucinous material in cell cytoplasm, CK20+, CEA+ (Surg Today 2009;39:619)
Angiosarcoma: squamous cell carcinoma can have anastomosing spaces mimicking neoplastic vessels of angiosarcoma and may not show keratinization; psseudovascular squamous cell carcinoma is negative for CD31, CD34 and Factor VIIII (Am J Surg Pathol 2004;28:298)

End of Colon tumor > Carcinoma > Squamous cell carcinoma of colon

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).