Squamous cell carcinoma of colon
Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 25 February 2012, last major update January 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Extremely rare
● Diagnosis of primary colonic tumor requires no involvement of cloacogenic or squamous lined mucosa, no squamous cell carcinoma elsewhere in body and generous sampling to exclude adenosquamous carcinoma (Surg Today 1994;24:75)
● Associated with ulcerative colitis (J Surg Oncol 1995;59:48), radiation therapy and schistosomiasis
● Aggressive (Saudi Med J 2006;27:874); often metastatic to liver, peritoneum or lung
● Favorable survival if node negative at presentation (Dis Colon Rectum 2001;44:341)
● May cause hypercalcemia (Dig Surg 2005;22:371)
● 54 year old man with elevated serum squamous cell carcinoma antigen (Clin Colorectal Cancer 2001;1:55)
● 59 year old woman with acantholytic variant of squamous carcinoma of cecum (Diagn Pathol 2011;6:5)
● 60 year old woman with colocutaneous fistula (World J Gastroenterol 2005;11:5251)
● In colon duplication (Cancer 1981;47:602)
● In villous adenoma (Hum Pathol 1988;19:362)
Primary Squamous cell carcinoma of cecum
● HPV (Eur J Surg Oncol 2002;28:657)
● Extension or metastasis from anal or other carcinomas: Eur J Cardiothorac Surg 2001;19:719
● Adenosquamous carcinoma: malignant glandular component with mucinous material in cell cytoplasm, CK20+, CEA+ (Surg Today 2009;39:619)
● Angiosarcoma: squamous cell carcinoma can have anastomosing spaces mimicking neoplastic vessels of angiosarcoma and may not show keratinization; psseudovascular squamous cell carcinoma is negative for CD31, CD34 and Factor VIIII (Am J Surg Pathol 2004;28:298)
End of Colon tumor > Carcinoma > Squamous cell carcinoma of colon
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