Colon tumor
Serrated polyp / adenoma

Author: Shilpa Jain, M.D. (see Authors page)

Revised: 19 December 2016, last major update August 2011

Copyright: (c) 2003-2016,, Inc.

PubMed search: "Serrated polyp" adenoma

Related topics: Sessile serrated adenomas
Cite this page: Serrated polyp / adenoma. website. Accessed December 13th, 2017.
Clinical features
Case reports
Gross description
  • Mean 6 - 9 mm
Microscopic (histologic) description
  • Variable, ranging from clearly adenomatous to resembling a hyperplastic polyp (Am J Surg Pathol 2003;27:65)
  • Proposed definition: surface epithelial nuclear dysplasia (elongation, increased N/C ratio, nucleoli and atypia) and serration of 20% + of lesional crypts (Mod Pathol 2003;16:417)
  • Left sided: have "normal proliferation" - less pronounced adenomatous features; may be vesicular cell type with prominent serration, irregular thickening of muscularis mucosa, decreased or dystrophic goblet cells, mucin in vesicular cells similar to hyperplastic polyp; also goblet cell type with less prominent serration but thick mucosa and thick basal membrane; also mucin poor type (rare) with prominent serration, no mucin
  • Right sided: usually large with abundant mucin (intra / extracellular), abnormal proliferation (i.e. adenomatous changes), dilated and distorted crypts and often secondary papillae
  • May coexist with colon carcinoma, with transition zone of tubulovillous adenoma (Am Surg 2010;76:E190)
Microscopic (histologic) images

Images hosted on other servers:

Various images

Various images

Serrated adenoma in hyperplastic polyposis

Pancolitis with low grade dysplastic lesion

Virtual slides

Images hosted on other servers:

Serrated adenoma

Positive stains
Molecular / cytogenetics description
Differential diagnosis