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Colon tumor

Carcinoma

Villous adenocarcinoma of colon


Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 1 August 2012, last major update January 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● 5% incidence in one study (World J Gastroenterol 1998;4:527)
● Pre-resection biopsies may not be diagnosed as carcinoma
● Appear to have a good prognosis
● May be associated with profound electrolyte disturbance (Ann Surg 1962;156:318)

Gross images
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Villous tumor with central ulceration

Micro description
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● Villous architecture in 50% or more
● Presence of epithelial islands in desmoplastic stroma is specific and 67% sensitive for carcinoma vs. adenoma (Am J Surg Pathol 2004;28:1460)

Micro images
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Contributed by Semir Vranic, M.D.
       

       

   
CDX2, CK20


   
Abrupt transition from benign to malignant mucosa

End of Colon tumor > Carcinoma > Villous adenocarcinoma of colon


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