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Colon tumor


Villous adenocarcinoma of colon

Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 1 August 2012, last major update January 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● 5% incidence in one study (World J Gastroenterol 1998;4:527)
● Pre-resection biopsies may not be diagnosed as carcinoma
● Appear to have a good prognosis
● May be associated with profound electrolyte disturbance (Ann Surg 1962;156:318)

Gross images

Villous tumor with central ulceration

Micro description

● Villous architecture in 50% or more
● Presence of epithelial islands in desmoplastic stroma is specific and 67% sensitive for carcinoma vs. adenoma (Am J Surg Pathol 2004;28:1460)

Micro images

Contributed by Semir Vranic, M.D.


CDX2, CK20

Abrupt transition from benign to malignant mucosa

End of Colon tumor > Carcinoma > Villous adenocarcinoma of colon

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