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Cite this page: World Health Organization (WHO) classification of colorectal carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colontumorwhoclassification.html. Accessed July 14th, 2017.
Definition / general
- WHO classification of tumors of the colon and rectum
- Currently on 4th edition, published in 2010
- Based on histologic appearance, not molecular characteristics
- Similar classification used in College of American Pathologists protocol for examination of colorectal carcinoma specimens
Classification
- Epithelial tumors:
- Premalignant lesions
- Adenoma
- Tubular
- Villous
- Tubulovillous
- Dysplasia (intraepithelial neoplasia, low grade)
- Dysplasia (intraepithelial neoplasia, high grade)
- Serrated lesions
- Hyperplastic polyp
- Sessile serrated adenoma / polyp
- Traditional serrated adenoma
- Hamartomas
- Cowden associated polyp
- Juvenile polyp
- Peutz-Jeghers polyp
- Carcinomas
- Adenocarcinoma
- Cribriform comedo type adenocarcinoma
- Medullary carcinoma
- Micropapillary carcinoma
- Mucinous adenocarcinoma
- Serrated adenocarcinoma
- Signet ring cell carcinoma
- Adenosquamous carcinoma
- Spindle cell carcinoma
- Squamous cell carcinoma
- Undifferentiated carcinoma
- Adenocarcinoma
- Neuroendocrine neoplasms
- Neuroendocrine tumor (NET)
- NET G1 (carcinoid)
- NET G2
- Neuroendocrine carcinoma (NEC)
- Large cell NEC
- Small cell NEC
- Mixed adenoneuroendocrine carcinoma
- EC cell, serotonin producing NET
- L cell, Glucagon-like peptide producing, and PP / PYY producing NETs
- Neuroendocrine tumor (NET)
- Premalignant lesions
- Mesenchymal tumors:
- Leiomyoma
- Lipoma
- Angiosarcoma
- Gastrointestinal stromal tumor
- Kaposi sarcoma
- Leiomyosarcoma
- Lymphomas
- Secondary tumors
Additional references
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