Colon non tumor
Infectious colitis (specific microorganisms)
Typhoid fever of colon

Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 January 2017, last major update November 2013

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: Typhoid fever of colon
Cite this page: Typhoid fever of colon. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colontyphoid.html. Accessed June 23rd, 2017.
Definition / general
  • Due to Salmonella typhi, which enters epithelial cells via cystic fibrosis transmembrane conductance regulator (CFTR mutations cause cystic fibrosis, Nature 1998;393:79)
  • Causes bacteremia, fever, chronic infection of joints, biliary tree, bones and meninges
  • Causes intestinal bleeding due to ulcers in distal ileum or proximal colon (Dig Liver Dis 2004;36:141)
  • Bleeding may be massive (Dis Colon Rectum 1986;29:511)
Case reports
Gross images

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Perforation at site of Peyer's patches

Microscopic (histologic) description
  • Hyperplasia, mucosal necrosis and sloughing, ulceration
  • Macrophages contain bacteria, red blood cells and lymphocytes
  • Macrophage aggregates are called typhoid nodules, present in intestine and nodes (also other sites)
Microscopic (histologic) images

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Typhoid nodules (microgranulomas) in ileal wall

Additional references