Colon (tumor & nontumor)
Other nonneoplastic

Topic Completed: 1 November 2013

Revised: 9 January 2019, last major update November 2013

Copyright: (c) 2003-2017,, Inc.

PubMed Search: colonic xanthoma

Raul S. Gonzalez, M.D.
Page views in 2019: 4,507
Page views in 2020 to date: 2,233
Cite this page: Gonzalez R. Xanthoma. website. Accessed August 12th, 2020.
Definition / general
  • Localized mass forming collection of lipid bearing histiocytes
  • Also called xanthomatous polyp, xanthogranulomatous inflammation, xanthelasma
  • Very rare in colon - stomach is most common gastrointestinal site
  • Colonic examples almost always rectosigmoid
  • May be due to prior injury
Clinical features
  • Colon polyp
  • May clinically resemble carcinoma
  • May cause intestinal obstruction if more extensive and involving deeper layers
Case reports
  • 38 year old woman with xanthogranulomatous inflammation presenting as a submucosal mass of the sigmoid colon (Pathol Int 2005;55:440)
  • 68 year old man with xanthoma disseminatum with large plaques confined to the back, pulmonary involvement and multiple intestinal xanthomas (Dermatology 2004;208:164)
Microscopic (histologic) description
  • Collection of foamy cells without mucin, typically limited to lamina propria
  • Associated with surface hyperplastic change (APMIS 2004;112:3)
Microscopic (histologic) images

Images hosted on other servers:

Prominent clusters of foamy histiocytes in colon polyp

Positive stains
Negative stains
Electron microscopy description
  • Electron dense globules
Differential diagnosis
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