Inflammatory / infectious / autoimmune / systemic disorders
Angiolymphoid hyperplasia with eosinophilia

Author: Nat Pernick, M.D. (see Authors page)

Revised: 8 February 2018, last major update October 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Angiolymphoid hyperplasia with eosinophilia [title] ear

Cite this page: Pernick, N. Angiolymphoid hyperplasia with eosinophilia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/earangiolymphoidhyperplasia.html. Accessed October 16th, 2018.
Definition / general
Case reports
  • Local excision or laser desiccation are usually curative
Gross description
  • Pink / red / brown cutaneous papules or subcutaneous nodules up to 1 cm
  • May coalesce to form plaque like lesions
Gross images

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Papule on ear

Microscopic (histologic) description
  • Unencapsulated but circumscribed
  • Dermal, nodular proliferation of granulation type tissue with haphazard, small caliber, irregularly shaped blood vessels with epithelioid endothelial cells containing hyperchromatic nuclei
  • Patchy lymphocytes, eosinophils and histiocytes
Microscopic (histologic) images

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Various images

Cytology description
  • Vascular structures, eosinophils, lymphocytes and clusters of cuboidal cells with vacuoles in abundant acidophilic cytoplasm (Diagn Cytopathol 1998;18:227)
  • No evidence of malignancy
Differential diagnosis
  • Angiosarcoma: anastomosing vascular channels lined by pleomorphic cells with increased mitotic activity, no inflammatory infiltrate
  • Hemangioma: no epithelioid endothelial cells, no inflammatory infiltrate
  • Kimura disease: large, deep, subcutaneous plaques in young Asian men, often regional lymphadenopathy, peripheral blood eosinophilia and elevated serum IgE levels; prominent lymphoid follicles and fibrosis with less prominent capillary proliferation, no aggregates of noncanalized endothelial cells