Inflammatory / infectious / autoimmune / systemic disorders

Author: Nat Pernick, M.D. (see Authors page)

Revised: 8 February 2018, last major update October 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Myospherulosis ear

Cite this page: Pernick, N. Myospherulosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/earmyospherulosis.html. Accessed June 20th, 2018.
Definition / general
  • Iatrogenic due to petrolatum based ointments
  • Usually nasal cavity and paranasal sinuses; occasionally affects middle ear
  • History of recent surgery with packing of area (Am J Clin Pathol 1977;67:118)
  • Associated with postoperative adhesions after sinus surgery (Laryngoscope 2003;113:1123)
Case reports
  • Symptomatic
Gross description
  • Ointment like material within granulation tissue
Microscopic (histologic) description
  • Pseudocysts within fibrous tissue with lymphocytes, histiocytes, giant cells and plasma cells
  • Pseudocysts contain "parent bodies" containing numerous spherules
Microscopic (histologic) images

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Missing Image

Aspergillus (figure 3)
and myospherulosis
(figure 4) in sinus
Negative stains
  • GMS for fungi