Inflammatory / infectious / autoimmune / systemic disorders

Topic Completed: 1 October 2013

Minor changes: 26 August 2019

Revised: 07 January 2019

Copyright: (c) 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Myospherulosis ear

Nat Pernick, M.D.
Page views in 2019: 153
Page views in 2020 to date: 131
Cite this page: Pernick N. Myospherulosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/earmyospherulosis.html. Accessed August 10th, 2020.
Definition / general
  • Iatrogenic due to petrolatum based ointments
  • Usually nasal cavity and paranasal sinuses; occasionally affects middle ear
  • History of recent surgery with packing of area (Am J Clin Pathol 1977;67:118)
  • Associated with postoperative adhesions after sinus surgery (Laryngoscope 2003;113:1123)
Case reports
  • Symptomatic
Gross description
  • Ointment like material within granulation tissue
Microscopic (histologic) description
  • Pseudocysts within fibrous tissue with lymphocytes, histiocytes, giant cells and plasma cells
  • Pseudocysts contain "parent bodies" containing numerous spherules
Microscopic (histologic) images

Images hosted on other servers:
Missing Image

Aspergillus (figure 3)
and myospherulosis
(figure 4) in sinus
Negative stains
  • GMS for fungi
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