CMV - cytomegalovirus

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 15 January 2018, last major update September 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: CMV cytomegalovirus esophagus[TIAB]

Cite this page: Weisenberg, E. CMV - cytomegalovirus. website. Accessed November 21st, 2018.
Definition / general
  • Histology is necessary to confirm diagnosis; repeat biopsy may be necessary
Case reports
Gross description
Microscopic (histologic) description
  • Virus present in enlarged endothelium and stromal cells at ulcer base
  • Basophilic cytoplasm often has coarse intracytoplasmic granules
  • Prominent intranuclear basophilic inclusions surrounded by clear halo
  • Macrophage aggregates in perivascular distribution are somewhat specific for CMV or HSV (Hum Pathol 1997;28:375); features are less obvious in patients receiving antiviral therapy
  • Inclusions are generally numerous but may be atypical in HIV patients (Hum Pathol 1992;23:1019)
Microscopic (histologic) images

Images hosted on other servers:

Intranuclear inclusions (H&E and EM)

H&E and CMV immunostain

CMV and leishmaniasis

Positive stains
  • CMV immunostain or in situ hybridization