Esophagus
Esophagitis
CMV - cytomegalovirus


Topic Completed: 1 September 2012

Revised: 12 February 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: CMV cytomegalovirus esophagus[TIAB]

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Cite this page: Weisenberg E. CMV - cytomegalovirus. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/esophagusCMVesophagitis.html. Accessed May 23rd, 2019.
Definition / general
Diagnosis
  • Histology is necessary to confirm diagnosis; repeat biopsy may be necessary
Case reports
Treatment
Gross description
Microscopic (histologic) description
  • Virus present in enlarged endothelium and stromal cells at ulcer base
  • Basophilic cytoplasm often has coarse intracytoplasmic granules
  • Prominent intranuclear basophilic inclusions surrounded by clear halo
  • Macrophage aggregates in perivascular distribution are somewhat specific for CMV or HSV (Hum Pathol 1997;28:375); features are less obvious in patients receiving antiviral therapy
  • Inclusions are generally numerous but may be atypical in HIV patients (Hum Pathol 1992;23:1019)
Microscopic (histologic) images

Images hosted on other servers:

Intranuclear inclusions (H&E and EM)

H&E and CMV immunostain

CMV and leishmaniasis

Positive stains
  • CMV immunostain or in situ hybridization
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