Graft versus host disease (GVHD)

Topic Completed: 1 October 2012

Revised: 6 September 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Graft versus host disease esophagus

Elliot Weisenberg, M.D.
Page views in 2018: 548
Page views in 2019 to date: 455
Cite this page: Weisenberg E. Graft versus host disease (GVHD). website. Accessed October 22nd, 2019.
Definition / general
Case reports
Gross description
  • Desquamative esophagitis with web formation
Microscopic (histologic) description
  • Increased intraepithelial lymphocytes, dyskeratotic squamous cells and apoptosis of individual squamous cells in noninflamed background is diagnostic
  • Also have increased submucosal fibrosis associated with mucosal esophagitis and ulceration (Gastroenterology 1981;80:914)
  • May be disparity between severity of clinical disease and biopsy findings
  • Findings may be focal, may need serial sections
Microscopic (histologic) images

Images hosted on other servers:

With lymphocytic infiltrate

Differential diagnosis
  • Scleroderma: fibrosis but no apoptotic squamous cells, different clinical history
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