Esophagus
Carcinoma
Adenosquamous

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 19 January 2018, last major update September 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Adenosquamous carcinoma esophagus

Cite this page: Weisenberg, E. Adenosquamous carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/esophagusadenosquamous.html. Accessed May 23rd, 2018.
Definition / general
  • Carcinoma that contains mixed elements of adenocarcinoma and squamous cell carcinoma, which remain clearly distinguishable within the tumor (WHO)
  • Most authorities reserve term for tumors with substantial elements of each component as minor divergent differentiation is not uncommon
Etiology
Clinical features
Diagnosis
  • Endoscopic biopsy
Case reports
Treatment
  • Resection if possible
  • Usually multimodality treatment
Microscopic (histologic) description
  • Admixed squamous cell carcinoma and adenocarcinoma
Microscopic (histologic) images

Images hosted on PathOut server:

Adenosquamous carcinoma

Positive stains
  • Rarely necessary
  • CD44 (in squamous areas), Alcian blue pH 2.5 in glandular component
Differential diagnosis