Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 19 January 2018, last major update September 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Adenosquamous carcinoma esophagus

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Cite this page: Weisenberg, E. Adenosquamous carcinoma. website. Accessed January 19th, 2019.
Definition / general
  • Carcinoma that contains mixed elements of adenocarcinoma and squamous cell carcinoma, which remain clearly distinguishable within the tumor (WHO)
  • Most authorities reserve term for tumors with substantial elements of each component as minor divergent differentiation is not uncommon
Clinical features
  • Endoscopic biopsy
Case reports
  • Resection if possible
  • Usually multimodality treatment
Microscopic (histologic) description
  • Admixed squamous cell carcinoma and adenocarcinoma
Microscopic (histologic) images

Images hosted on PathOut server:

Adenosquamous carcinoma

Positive stains
  • Rarely necessary
  • CD44 (in squamous areas), Alcian blue pH 2.5 in glandular component
Differential diagnosis